Effects of methylphenidate and atomoxetine treatment on Purkinje cell number in juvenile rats
Yazarlar (9)
Tolgahan Acar
Şifa Üniversitesi, Türkiye
Şifa Üniversitesi, Türkiye
Berrin Zuhal Altunkaynak Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Kıymet Kübra TÜFEKCİ Ondokuz Mayis Üniversitesi, Türkiye
Murat Yuce
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Habib Khoshvaghti Adiyaman Üniversitesi, Türkiye
Elfide Gizem Kivrak Ondokuz Mayis Üniversitesi, Türkiye
Ebru Elibol Ondokuz Mayis Üniversitesi, Türkiye
Mehmet Emin Onger Ondokuz Mayis Üniversitesi, Türkiye
Öğr. Gör. Süleyman Kaplan Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Analytical and Quantitative Cytopathology and Histopathology (Q4) | ||
| Dergi ISSN | 2578-742X Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Cilt / Sayı / Sayfa | 38 / 6 / 343–349 | DOI | – |
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| OBJECTIVE: To detect the effects of methylphenidate (MPH) and atomoxetine (ATX) on the cerebellum. STUDY DESIGN: Male juvenile rats were separated into MPH, ATX, and control groups. The amount of Purkinje cells and the histological structure of the cerebellum were investigated.RESULTS: In the MPH group a significant increase was noted in the number of Purkinje cells as compared with the other groups. Also, it was observed that the number of Purkinje cells increased in the ATX groups. The histopathological results showed that MPH and especially ATX caused pyknotic nuclei and irregular cell boundaries in some Purkinje cells. CONCLUSION: MPH and ATX can be used to reduce attention-deficit hyperactivity disorder symptoms. We detected that MPH administration caused an increase but ATX caused a decrease in Purkinje cell numbers. Our data provides evidence to answer questions about the … |
| Anahtar Kelimeler |
| ADD | ADDH | ADHD | Adolescence | Adolescent psychology | Atomoxetine | Atomoxetine hydrochloride | Attention deficit disorder | Attention deficit disorder with hyperactivity | Attention deficit hyperactivity disorder | Cerebellum | Methylphenidate | Methylphenidate hydrochloride | N-methylgamma-( 2-methylphenoxy)benzenepropanamine hydrochloride | Neurodevelopmental disorders | Purkinje cells | Stereology |
