The use of diclofenac sodium in urological practice: A structural and neurochemical based review
Yazarlar (4)
Mahmut Ulubay Gazi Hospital, Türkiye
Doç. Dr. Kıymet Kübra TÜFEKCİ Ondokuz Mayis Üniversitesi, Türkiye
Dr. Öğr. Üyesi Arife Ahsen Kaplan Ondokuz Mayis Üniversitesi, Türkiye
Mustafa Kemal Atilla Samsun Training And Research Hospital, Türkiye
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) (SCI, SSCI, AHCI, SCI-Exp dergilerinde yayınlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale) | ||
| Dergi Adı | Journal of Chemical Neuroanatomy | ||
| Dergi ISSN | 0891-0618 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2018 |
| Cilt / Sayı / Sayfa | 87 / 1 / 32–36 | DOI | 10.1016/j.jchemneu.2017.02.005 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0891061816302459 | ||
| UAK Araştırma Alanları |
Üroloji
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| Özet |
| Diclofenac sodium (DS) is a non-steroidal anti-inflammatory drug with antipyretic and analgesic effects. It is mainly found in the form of sodium salt. The mechanism of action of DS operates by way of cyclooxygenase (COX) inhibition. The physiological effect of this substance derives from a decrease in prostaglandin production. DS is a benzeneacetic acid derivative with anti-inflammatory properties. As a non-steroidal anti-inflammatory drug (NSAID), DS binds to both forms of COX (COX-1 and COX-2) and inhibits the conversion of arachidonic acid into pro-inflammatory prostaglandins by means of chelation. At the same time, this agent is also able to inhibit tumor angiogenesis, in which COX-2 is involved. DS is effective in overcoming pain and inflammation when it inhibits COX-2, but gastrointestinal side effects appear when it inhibits COX-1. In this review, we have focused on chemical structure and … |
| Anahtar Kelimeler |
| Cyclooxygenase | Diclofenac sodium | Nanoparticles | Urology |
Science Direct
The use of diclofenac sodium in urological practice: A structural and neurochemical based review
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 25 |
| Scopus | 33 |
| Google Scholar | 55 |