| Yazarlar |
Mahmut Ulubay
Sağlık Bilimleri Üniversitesi, Türkiye |
Doç. Dr. Kıymet Kübra TÜFEKCİ
Ondokuz Mayıs Üniversitesi, Türkiye |
|
Arife Ahsen Kaplan
|
|
Mustafa Kemal Atilla
Sağlık Bilimleri Üniversitesi, Türkiye |
| Özet |
| Diclofenac sodium (DS) is a non-steroidal anti-inflammatory drug with antipyretic and analgesic effects. It is mainly found in the form of sodium salt. The mechanism of action of DS operates by way of cyclooxygenase (COX) inhibition. The physiological effect of this substance derives from a decrease in prostaglandin production. DS is a benzeneacetic acid derivative with anti-inflammatory properties. As a non-steroidal anti-inflammatory drug (NSAID), DS binds to both forms of COX (COX-1 and COX-2) and inhibits the conversion of arachidonic acid into pro-inflammatory prostaglandins by means of chelation. At the same time, this agent is also able to inhibit tumor angiogenesis, in which COX-2 is involved. DS is effective in overcoming pain and inflammation when it inhibits COX-2, but gastrointestinal side effects appear when it inhibits COX-1. In this review, we have focused on chemical structure and pharmacokinetic properties and renal effects of DS in light of current knowledge. Additionally, use of diclofenac nanoparticles were also discussed. |
| Anahtar Kelimeler |
| Cyclooxygenase | Diclofenac sodium | Nanoparticles | Urology |
| Makale Türü | Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri) |
| Makale Alt Türü | SCI, SSCI, AHCI, SCI-Exp dergilerinde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale |
| Dergi Adı | JOURNAL OF CHEMICAL NEUROANATOMY |
| Dergi ISSN | 0891-0618 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2018 |
| Cilt No | 87 |
| Sayı | 1 |
| Sayfalar | 32 / 36 |
| Doi Numarası | 10.1016/j.jchemneu.2017.02.005 |
| Atıf Sayıları | |
| WoS | 23 |
| SCOPUS | 30 |
| Google Scholar | 45 |
