Effect of different doses of diclofenac sodium on the hippocampus development during the first trimester of pregnancy
Yazarlar (8)
Doç. Dr. Ebru Annaç Türkiye
Öğr. Gör. Süleyman Kaplan Türkiye
Prof. Dr. Abdurrahman Aksoy Türkiye
Doç. Dr. Kıymet Kübra TÜFEKCİ Türkiye
Gamze Altun Türkiye
Prof. Dr. Mehmet Emin Önger Türkiye
| Bildiri Türü | Tebliğ/Bildiri | Bildiri Dili | İngilizce |
| Bildiri Alt Türü | Özet Metin Olarak Yayınlanan Tebliğ (Uluslararası Kongre/Sempozyum) | ||
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum | ||
| DOI Numarası | 10.5835/jecm.omu.31.02.028 | ||
| Kongre Adı | The First Asian and African Stereology Congress | ||
| Kongre Tarihi | 06-11-2012 / 08-11-2012 | ||
| Basıldığı Ülke | Basıldığı Şehir | ||
| Bildiri Linki | http://dx.doi.org/120 | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| In the present study it was aimed to investigate the toxic effects of different doses ofdiclofenac sodium on the rat hippocampus that is exposed during first trimester of prenatalperiod using stereological and histopathological techniques. For this aim, 30 maleoffspring Wistar albino rats were used. The subjects were divided into five main groups.These are pure control, saline, low dose (3.9 mg/kg), medium dose (9 mg/kg) and highdose (18 mg/kg). These doses are given during the first trimester (0-7 days) of pregnancy.After delivery; on the 8th day of the postnatal life, all animals were euthanized with anoverdose of aesthetic. Then, the brain tissue samples were analysed by histological andstereological techniques. In the diclofenac sodium administered groups it was observeda significant decrease in terms of the average neuron number in the CA1, CA2 and CA3regions and whole hippocampus compared to the pure control and the saline groups.When it was compared to CA regions of hippocampus among themselves, there was asignificant dose dependent effect in terms of the average neuron number in the CA1 andCA3 regions but not in CA2 region. Light microscopic investigation of the drug administeredgroups indicated significant decrease in the number of healthy neurons. Additionallyin the high dose group, it was identified more necrotic neurons compared to the othergroups. It was found that diclofenac sodium causes decreasing the number of the neuronsin the CA1, CA2, and CA3 regions and whole hippocampus. Although dose-dependenteffects of diclofenac sodium on the number of neurons in CA1 and CA3 regions wereseen, this … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Google Scholar | 1 |