Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure
Yazarlar (9)
Doç. Dr. Selim Çomaklı Atatürk Üniversitesi, Türkiye
Doç. Dr. Çiğdem SEVİM Atatürk Üniversitesi, Türkiye
George Kontadakıs
University Of Crete Medical School, Yunanistan
University Of Crete Medical School, Yunanistan
Prof. Dr. Elif DOĞAN Atatürk Üniversitesi, Türkiye
Doç. Dr. Ali Taghizadehghalehjoughi Atatürk Üniversitesi, Türkiye
Prof. Dr. Mustafa Özkaraca Atatürk Üniversitesi, Türkiye
Mıchael Aschner
Albert Einstein College Of Medicine, Amerika Birleşik Devletleri
Albert Einstein College Of Medicine, Amerika Birleşik Devletleri
Taxıarchıs Konstantınos Nıkolouzakıs
University Of Crete, Yunanistan
University Of Crete, Yunanistan
Arıstıdes Tsatsakıs
University Of Crete Medical School, Yunanistan
University Of Crete Medical School, Yunanistan
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | Toxicology Reports | ||
| Dergi ISSN | 2214-7500 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | Scopus | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2019 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2019 |
| Cilt / Sayı / Sayfa | 6 / 1 / 155–160 | DOI | 10.1016/j.toxrep.2019.01.004 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S2214750018307819 | ||
| Özet |
| Glufosinate is a common herbicide with neurotoxic effects, leading to seizures, convulsions and memory loss. Glufosinate indirectly induces glutamate toxicity by inhibiting glutamine synthesis in astrocytes. Here, we studied the acute toxic effects of a glufosinate-based herbicide in rat optic nerve at three doses (40, 80 or 120 μM, equal to 714 or 21 mg/kg bw/day). Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, glucose, calcium, as well as creatinine concentrations were analyzed after 24, 48 and 72 h treatment. Intraocular pressure (IOP) (expressed as the average of both eyes) was measured with a rebound tonometer. Interleukin-1β (IL-1β) and c-Fos expression were determined by immunohistochemistry. The results established that the glufosinate-based herbicide significantly increased IL-1β and c-Fos immunopositivity in the optic nerve (p < 0.05), concomitant with increased IOP. These results suggest that commercial formulations of glufosinate acutely affect the optic nerve. |
| Anahtar Kelimeler |
| c-fos | Glufosinate | Interleukin-1β | Intraocular pressure |
Science Direct
Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 16 |