Pharmacokinetics of florfenicol after intravenous and intramuscular administration in New Zealand White rabbits
 
Yazarlar (6)
F. Koc Atatürk Üniversitesi, Türkiye
M. Ozturk Atatürk Üniversitesi, Türkiye
Y. Kadioglu Atatürk Üniversitesi, Türkiye
Prof. Dr. Elif DOĞAN Atatürk Üniversitesi, Türkiye
L. E. Yanmaz Atatürk Üniversitesi, Türkiye
Z. Okumus Atatürk Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Research in Veterinary Science
Dergi ISSN 0034-5288 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 01-2009
Kabul Tarihi Yayınlanma Tarihi 01-08-2009
Cilt / Sayı / Sayfa 87 / 1 / 102–105 DOI 10.1016/j.rvsc.2008.10.010
Makale Linki https://linkinghub.elsevier.com/retrieve/pii/S0034528808002270
Özet
The pharmacokinetic disposition and bioavailability of florfenicol (FF) were determined after single intravenous (i.v.) and intramuscular (i.m.) administrations of 25 mg/kg b.w. to ten healthy New Zealand White rabbits. Plasma FF concentrations were determined by high-performance liquid chromatography (HPLC). The plasma pharmacokinetic values for FF were best described by a one-compartment open model. The elimination half-life (t1/2β) was different (p < 0.05) however, the area under curve (AUC) was similar (p > 0.05) after i.v. and i.m. administrations. FF was rapidly eliminated (t1/2β 1.49 ± 0.23 h), slowly absorbed and high (F, 88.75 ± 0.22%) after i.m. injection. In addition, FF was widely distributed to the body tissues (Vss 0.98 ± 0.05 L/kg) after i.v. injection. In this study the time that plasma concentration exceeded the concentration of 2 μg/mL was approximately 6 h. For bacteria with MIC of 2 μg/mL, frequent administration at this dose would be needed to maintain the concentration above the MIC. However, it is possible that rabbit pathogens may have MIC values less than 2 μg/mL which would allow for less frequent administration. Further studies are necessary to identify the range of MIC values for rabbit pathogens and to identify the most appropriate PK-PD parameter needed to predict an effective dose. Crown Copyright © 2008.
Anahtar Kelimeler
Florfenicol | Pharmacokinetic | Plasma | Rabbit