| Yazarlar |
Feride Koç
Erciyes Üniversitesi, Türkiye |
|
Murat Öztürk
Kocaeli Üniversitesi, Türkiye |
|
Yücel Kadıoğlu
Atatürk Üniversitesi, Türkiye |
Doç. Dr. Elif DOĞAN
Atatürk Üniversitesi, Türkiye |
|
Latif Emrah Yanmaz
Atatürk Üniversitesi, Türkiye |
|
Zafer Okumuş
Atatürk Üniversitesi, Türkiye |
| Özet |
| The pharmacokinetic disposition and bioavailability of florfenicol (FF) were determined after single intravenous (i.v.) and intramuscular (i.m.) administrations of 25 mg/kg b.w. to ten healthy New Zealand White rabbits. Plasma FF concentrations were determined by high-performance liquid chromatography (HPLC). The plasma pharmacokinetic values for FF were best described by a one-compartment open model. The elimination half-life (t1/2β) was different (p < 0.05) however, the area under curve (AUC) was similar (p > 0.05) after i.v. and i.m. administrations. FF was rapidly eliminated (t1/2β 1.49 ± 0.23 h), slowly absorbed and high (F, 88.75 ± 0.22%) after i.m. injection. In addition, FF was widely distributed to the body tissues (Vss 0.98 ± 0.05 L/kg) after i.v. injection. In this study the time that plasma concentration exceeded the concentration of 2 μg/mL was approximately 6 h. For bacteria with MIC of 2 μg/mL, frequent administration at this dose would be needed to maintain the concentration above the MIC. However, it is possible that rabbit pathogens may have MIC values less than 2 μg/mL which would allow for less frequent administration. Further studies are necessary to identify the range of MIC values for rabbit pathogens and to identify the most appropriate PK-PD parameter needed to predict an effective dose. Crown Copyright © 2008. |
| Anahtar Kelimeler |
| Pharmacokinetic,Florfenicol,Rabbit,Plasma |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Researh in veterinary science |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2009 |
| Cilt No | 87 |
| Sayı | 1 |
| Sayfalar | 102 / 105 |
