| Yazarlar |
Koc F
|
|
Kaynar O
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|
Okumus Z
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|
Dogan E
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Yanmaz LE
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| Özet |
| The aim of this study was to investigate pharmacokinetics and penetration into the aqueous humor of Long Action Oxytetracycline (OTC-LA) after Intravenous (IV) and Intramuscular (IM) administrations, at a single dose of 20 mg kg-1 b.wt in rabbits. After administrations of the long action formulation, the plasma oxytetracycline concentrations were evaluated using a two-compartmental open model. The study was designed according to a two-period cross-over and the plasma OTC concentration was measured using the ELISA procedure. The elimination half-lives (t1/2β) of the OTC-LA after IV and IM administrations were 12.60±0.92 and 38.67±4.40 h, respectively. After IV administration, the volume of distribution (Vdss) and total body Clearance (Cltot) values of the drug were 3.42±0.21 L kg-1 and 0.19±0.01 L/h/kg, respectively. The maximum concentration of the drug (Cmax) in the plasma (4.23±0.43 μg mL-1) was achieved at 2.0 h (tmax) after IM administration. The Minimum therapeutic plasma Concentration (MIC) of the drug at the amount >0.5 μg mL-1 was maintained until 48 h after IV and IM administrations. The intramuscular bioavailabihty of the drug was 0.79±0.10%. After IV and IM administrations of OTC-LA formulation, the maximum concentrations of the drug in the aqueous humor were 0.1 and 0.068 μg mL-1, respectively. However, the concentrations of the drug in the aqueous humor were below the MIC value (0.5 μgmL-1) during 12-72 and 4-48 h for IM and IV administrations, respectively. © Medwell Journals, 2009. |
| Anahtar Kelimeler |
| Oxytetracycline,rabbit,aqueous humor,pharmacokinetics,plasma,intravenous |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of animal and veterinary advances |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2009 |
| Cilt No | 8 |
| Sayı | 10 |
| Sayfalar | 1900 / 1905 |
