| Yazarlar |
Doç. Dr. Emine PETEKKAYA
Kastamonu Üniversitesi, Türkiye |
Berna Kuş
|
|
Serdar Doğan
Türkiye |
|
Hanifi Bayaroğulları
Türkiye |
|
Turay Mutlu
Türkiye |
|
İsmet Murat Melek
Türkiye |
|
Abdullah Arpacı
Türkiye |
| Özet |
| The purpose of this study is to determine the volumes of primary brain regions associated with smell and taste in Alzheimer's and Parkinson's patients and healthy controls using MR imaging and examine volumetric changes in comparison to smell/taste questionnaire and test results and endocannabinoid (EC) levels. The study included 15 AD patients with mild cognitive dysfunction scored as 18 ≤ MMSE ≤ 23, 15 PD patients with scores of 18 < MoCA < 26 and 18 ≤ MMSE ≤ 23, and 15 healthy controls. A taste and smell questionnaire was given to the participants, and their taste and smell statuses were examined using the Sniffin' Sticks smell identification test and Burghart Taste Strips. EC levels were analyzed in the blood serum samples of the participants using the ELISA method. The volumes of the left olfactory bulb (p = 0.001), left amygdala (p = 0.004), left hippocampus (p = 0.008), and bilateral insula (left p = 0.000, right p = 0.000) were significantly smaller in the Alzheimer's patients than the healthy controls. The volumes of the left olfactory bulb (p = 0.001) and left hippocampus (p = 0.009) were significantly smaller in the Parkinson's patients than the healthy controls. A significant correlation was determined between volume reduction in the left Rolandic operculum cortical region and taste dysfunction. EC levels were significantly higher in both AD (p = 0.000) and PD (p = 0.006) in comparison to the controls. Our results showed that volumetric changes occur in the brain regions associated with smell and taste in Alzheimer's and Parkinson's patients. It was observed that ECs played a role in these volumetric changes and the olfactory and taste dysfunctions of the patients. |
| Anahtar Kelimeler |
| Olfactory/taste dysfunction,Sniffin' Sticks test,Burghart taste strips,Neurodegenerative disease,Endocannabinoid,Alzheimer disease,Parkinson disease |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Clinical Neuroscience |
| Dergi ISSN | 0967-5868 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2022 |
| Cilt No | 100 |
| Sayfalar | 52 / 58 |
| Doi Numarası | 10.1016/j.jocn.2022.03.047 |
| Makale Linki | https://reader.elsevier.com/reader/sd/pii/S0967586822001497?token=B695BAC5F9AD4E2A79A5EE476BE8FE7A37094F1F0B17AD00048EC585DCA94DE43124131AF6C67589DA2433FC00FB123B&originRegion=eu-west-1&originCreation=20220407211105 |
| Atıf Sayıları | |
| WoS | 5 |
