| Yazarlar |
Hatem Kazımoğlu
Sanko Üniversitesi, Türkiye |
|
Erdal Uysal
Sanko Üniversitesi, Türkiye |
|
Mehmet Dokur
Biruni Üniversitesi, Türkiye |
|
Ahmet Orhan Gürer
Sanko Üniversitesi, Türkiye |
|
Kadir Batçıoğlu
İnönü Üniversitesi, Türkiye |
|
Ayşe Burçin Uyumlu
İnönü Üniversitesi, Türkiye |
|
Emine Petekkaya
Kastamonu Üniversitesi, Türkiye |
|
Mehmet Karadağ
Hatay Mustafa Kemal Üniversitesi, Türkiye |
| Özet |
| This study aims to compare the protective effects of ambrisentan, a selective endothelin typeA receptor antagonist, and bosentan, a dual endothelin typeA/B receptor antagonist, on experimental renal ischemia reperfusion injury. The study sample consisted of 21 female rats, which were divided into 3 groups: Control, Ambrisentan and Bosentan. For the ischemia-reperfusion injury model, left‑kidney nephrectomy was performed after sacrificing the animals. In the immunohistochemical examination, caspase-3 was examined, and then the apoptotic index was determined. In the biochemical examination, the activities of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase, and the levels of nitrite (NOx), TNF-α, and IL-1β were determined. There were statistically significant differences between the groups in terms of total injury score grade in range of 0‒3 (p=0.001).The glomerular and tubular apoptotic indices were higher in the control group as compared to those of the ambrisentan and bosentan groups (p=0.001).There were no statistically significant differences in terms of SOD, CAT, GPx, MDA, IL-1β and TNF-α measurements among the groups (p>0.05). In the experimentally created renal ischemia reperfusion model, both ambrisentan and bosentan increased the NOx level, decreased the apoptosis, and protected the kidney from renal ischemia reperfusion injury. However, no significant superiority was found between ambrisentan and bosentan in terms of their protective effects (Tab. 3, Fig. 2, Ref. 31). |
| Anahtar Kelimeler |
| ambrisentan | apoptosis | bosentan rat. | ischemia-reperfusion | kidney |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | BRATISLAVA MEDICAL JOURNAL |
| Dergi ISSN | 1336-0345 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2020 |
| Cilt No | 121 |
| Sayı | 8 |
| Sayfalar | 547 / 553 |
| Doi Numarası | doi: 10.4149/BLL_2020_091. |
| Makale Linki | https://europepmc.org/article/med/32726116 |
| Atıf Sayıları | |
| WoS | 1 |
