| Yazarlar (7) |
Hakan Kandemir
Tekirdağ Namık Kemal Üniversitesi, Türkiye |
|
Samet İzgi
Tekirdağ Namık Kemal Üniversitesi, Türkiye |
Doç. Dr. İrfan ÇINAR
Kastamonu Üniversitesi, Türkiye |
|
Fatma Cebeci
Bayburt Üniversitesi, Türkiye |
|
Ebubekir Dirican
Bayburt Üniversitesi, Türkiye |
|
Mehmet F. Saglam
Gebze Teknik Üniversitesi, Türkiye |
|
Ibrahim F. Sengul
Gebze Teknik Üniversitesi, Türkiye |
| Özet |
| Indole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, a new range of indole-7-carbohydrazides has been successfully synthesized starting from the readily available 3-phenyl and 2,3-diphenyl 4,6-dimethoxyindoles. The structures of the novel compounds were confirmed by utilizing 1H NMR, 13C NMR, FT-IR, high-resolution mass spectrometry, and single crystal X- ray diffraction techniques. In addition, the indole-7-carbohydrazides showed promising antioxidant results in preliminary screens. Some of the new compounds generated from dimethoxy indoles were also screened for their anticancer activity against SH-SHY5Y (human neuroblastoma), AGS (human gastric adenocarcinoma), and MDA-MB-231 (human breast adenocarcinoma) cell lines. The results revealed that the compound 12 was the promising candidate, showing cytotoxic effects on both neuroblastoma, stomach, and breast cancer cells. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | JOURNAL OF HETEROCYCLIC CHEMISTRY |
| Dergi ISSN | 0022-152X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2023 |
| Cilt No | 60 |
| Sayı | 1 |
| Sayfalar | 74 / 85 |
| Doi Numarası | 10.1002/jhet.4562 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/full/10.1002/jhet.4562 |
| Atıf Sayıları | |
| WoS | 3 |
| SCOPUS | 3 |
| Google Scholar | 5 |
