Methoxy-activated indole-7-carbohydrazides; synthesis, antioxidant, and anticancer properties
Yazarlar (7)
Hakan Kandemir Tekirdağ Namık Kemal Üniversitesi, Türkiye
Samet İzgi Tekirdağ Namık Kemal Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Fatma Cebeci Bayburt Üniversitesi, Türkiye
Doç. Dr. Ebubekir Dirican Bayburt Üniversitesi, Türkiye
Mehmet F. Saglam Gebze Teknik Üniversitesi, Türkiye
Ibrahim F. Sengul Gebze Teknik Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Heterocyclic Chemistry (Q2) | ||
| Dergi ISSN | 0022-152X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2023 |
| Cilt / Sayı / Sayfa | 60 / 1 / 74–85 | DOI | 10.1002/jhet.4562 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/full/10.1002/jhet.4562 | ||
| Özet |
| Indole has been known as a key heterocyclic motif in the development of new structures for both chemical and biological properties. In this current study, a new range of indole‐7‐carbohydrazides has been successfully synthesized starting from the readily available 3‐phenyl and 2,3‐diphenyl 4,6‐dimethoxyindoles. The structures of the novel compounds were confirmed by utilizing 1H NMR, 13C NMR, FT‐IR, high‐resolution mass spectrometry, and single crystal X‐ ray diffraction techniques. In addition, the indole‐7‐carbohydrazides showed promising antioxidant results in preliminary screens. Some of the new compounds generated from dimethoxy indoles were also screened for their anticancer activity against SH‐SHY5Y (human neuroblastoma), AGS (human gastric adenocarcinoma), and MDA‐MB‐231 (human breast adenocarcinoma) cell lines. The results revealed that the compound 12 was the promising … |
| Anahtar Kelimeler |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 3 |
| Google Scholar | 5 |