Gossypin mitigates oxidative damage by downregulating the molecular signaling pathway in oleic acid‐induced acute lung injury
Yazarlar (5)
Doç. Dr. Büşra Dincer Ondokuz Mayıs Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Kastamonu Üniversitesi, Türkiye
Doç. Dr. Beste DEMİRCİ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Funda TERZİ Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Recognition (Q3) | ||
| Dergi ISSN | 0952-3499 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 09-2023 |
| Cilt / Sayı / Sayfa | 36 / 11 / 1–16 | DOI | 10.1002/jmr.3058 |
| Makale Linki | http://dx.doi.org/10.1002/jmr.3058 | ||
| Özet |
| One of the leading causes of acute lung injury, which is linked to a high death rate, is pulmonary fat embolism. Increases in proinflammatory cytokines and the production of free radicals are related to the pathophysiology of acute lung injury. Antioxidants that scavenge free radicals play a protective role against acute lung injury. Gossypin has been proven to have antioxidant, antimicrobial, and anti‐inflammatory properties. In this study, we compared the role of Gossypin with the therapeutically used drug Dexamethasone in the acute lung injury model caused by oleic acid in rats. Thirty rats were divided into five groups; Sham, Oleic acid model, Oleic acid+Dexamethasone (0.1 mg/kg), Oleic acid+Gossypin (10 and 20 mg/kg). Two hours after pretreatment with Dexamethasone or Gossypin, the acute lung injury model was created by injecting 1 g/kg oleic acid into the femoral vein. Three hours following the oleic … |
| Anahtar Kelimeler |
| acute lung injury | dexamethasone | Gossypin | oleic acid | oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 3 |