Antipsychotics Induced Reproductive Toxicity by Stimulating Oxidative Stress: A Comparative in Vivo and in Silico Study.
Yazarlar (8)
Doç. Dr. Büşra Dincer Ondokuz Mayis Üniversitesi, Türkiye
Ahmet Bülent Yazıcı Sakarya Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Erdem Toktay Kafkas Üniversitesi, Türkiye
Jale Selli Alanya Alaaddin Keykubat University, Türkiye
Prof. Dr. Elif Çadırcı Ataturk University, Faculty Of Medicine, Türkiye
Doç. Dr. Zafer Bayraktutan Ataturk University, Faculty Of Medicine, Türkiye
Esra Yazıcı Sakarya Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Chemistry and Biodiversity (Q3) | ||
| Dergi ISSN | 1612-1872 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2023 |
| Cilt / Sayı / Sayfa | 20 / 5 / – | DOI | 10.1002/cbdv.202201190 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/full/10.1002/cbdv.202201190 | ||
| Özet |
| The pathophysiological mechanism behind the link between antipsychotic drugs and sexual dysfunction is still unknown. The goal of this research is to compare the potential effects of antipsychotics on the male reproductive system. Fifty rats were randomly assigned into the five groups indicated: Control, Haloperidol, Risperidone, Quetiapine and Aripiprazole. Sperm parameters were significantly impaired in all antipsychotics‐treated groups. Haloperidol and Risperidone significantly decreased the level of testosterone. All antipsychotics had significantly reduced inhibin B level. A significant reduction was observed in SOD activity in all antipsychotics‐treated groups. While GSH levels diminished, MDA levels were rising in the Haloperidol and Risperidone groups. Also, the GSH level was significantly elevated in the Quetiapine and Aripiprazole groups. By causing oxidative stress and altering hormone levels … |
| Anahtar Kelimeler |
| biological activity | medicinal chemistry | toxicology |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 5 |
| Google Scholar | 7 |