| Yazarlar |
Büşra Dincer
Türkiye |
|
Ahmet Bülent Yazıcı
Türkiye |
Doç. Dr. İrfan ÇINAR
Kastamonu Üniversitesi, Türkiye |
|
Erdem Toktay
Türkiye |
|
Jale Selli
Türkiye |
|
Elif Çadırcı
Türkiye |
|
Zafer Bayraktutan
Türkiye |
|
Esra Yazıcı
Türkiye |
| Özet |
| The pathophysiological mechanism behind the link between antipsychotic drugs and sexual dysfunction is still unknown. The goal of this research is to compare the potential effects of antipsychotics on the male reproductive system. Fifty rats were randomly assigned into the five groups indicated: Control, Haloperidol, Risperidone, Quetiapine and Aripiprazole. Sperm parameters were significantly impaired in all antipsychotics-treated groups. Haloperidol and Risperidone significantly decreased the level of testosterone. All antipsychotics had significantly reduced inhibin B level. A significant reduction was observed in SOD activity in all antipsychotics-treated groups. While GSH levels diminished, MDA levels were rising in the Haloperidol and Risperidone groups. Also, the GSH level was significantly elevated in the Quetiapine and Aripiprazole groups. By causing oxidative stress and altering hormone levels, Haloperidol and Risperidone are damaging to male reproductivity. This study represents useful starting point for exploring further aspects of the underlying mechanisms reproductive toxicity of antipsychotics. |
| Anahtar Kelimeler |
| biological activity | medicinal chemistry | toxicology |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Chemistry & biodiversity |
| Dergi ISSN | 1612-1872 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2023 |
| Doi Numarası | 10.1002/cbdv.202201190 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/full/10.1002/cbdv.202201190 |
| Atıf Sayıları | |
| SCOPUS | 1 |
