Selenium reduces acrylamide-induced testicular toxicity in rats by regulating HSD17B1, StAR, and CYP17A1 expression, oxidative stress, inflammation, apoptosis, autophagy, and DNA damage
Yazarlar (7)
Prof. Dr. Serkan Yıldırım Atatürk Üniversitesi, Türkiye
Prof. Dr. Emin Şengül Atatürk Üniversitesi, Türkiye
Prof. Dr. Emrah Hicazi Aksu Kastamonu Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Volkan Gelen Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Samet Tekin Atatürk Üniversitesi, Türkiye
Yusuf Dağ Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Environmental Toxicology (Q1) | ||
| Dergi ISSN | 1520-4081 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2023 |
| Cilt / Sayı / Sayfa | 39 / 3 / 1402–1414 | DOI | 10.1002/tox.23996 |
| Makale Linki | 10.1002/tox.23996 | ||
| Özet |
| This study investigated the effects of Selenium (Se) on testis toxicity induced by Acrylamide (ACR) in rats. In our study, 50 male adult rats were used, and the rats were divided into five groups; control, ACR, Se0.5 + ACR, Se1 + ACR, and Se1. Se and ACR treatments were applied for 10 days. On the 11th day of the experimental study, intracardiac blood samples from the rats were taken under anesthesia and euthanized. Sperm motility and morphology were evaluated. Dihydrotestosterone, FSH, and LH levels in sera were analyzed with commercial ELISA kits. MDA, GSH, TNF‐α, IL‐6, and IL‐1β levels and SOD, GPx, and CAT, activities were measured to detect the level of oxidative stress and inflammation in rat testis tissues. Expression analysis of HSD17B1, StAR, CYP17A1, MAPk14, and P‐53 as target mRNA levels were performed with Real Time‐PCR System technology for each cDNA sample … |
| Anahtar Kelimeler |
| acrylamide | follicle-stimulating hormone | inflammation | luteinizing hormone | oxidative stress | rat | selenium |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |
| Scopus | 19 |
| Google Scholar | 24 |