| Yazarlar |
Şaziye Sezin Yücelik
Atatürk Üniversitesi, Türkiye |
|
Naciye Dilara Zeybek
Türkiye |
Doç. Dr. İrfan ÇINAR
Kastamonu Üniversitesi, Türkiye |
|
Erol Akpınar
Türkiye |
|
Elham Bahador Zırh
Türkiye |
|
Hande Sipahi
Türkiye |
|
Zekai Halıcı
Türkiye |
| Özet |
| Chronic aluminium(Al) exposure can affect the antioxidant and glutaminergic systems through N-methyl-D-aspartate receptors (NMDAR). This study was aimed to investigate the neurotoxic effect of Al through different mechanisms in rat hippocampus and to evaluate the protective role of epigallocatechin gallate (EGCG), a well-known antioxidant, with simultaneous administration of Al,as well as post-treatment after Al exposure.For this purpose, aluminum chloride(AlCl3) was administered simultaneously with two different EGCG doses for 8 weeks as the first part of the study.In the second part of the study, after 4 weeks of AlCl3 pre-administration, two different EGCG doses were also administered during four additional weeks as post-treatment.Al administration led to oxidative stress and increased acetylcholinesterase levels.NMDAR subunit mRNA expressions were down-regulated by Al, which was apparent in NMDAR1/2B subunits.Simultaneous EGCG treatment has shown a better neuroprotective effect in terms of these mechanisms and represents novel approach for the prevention of neurodegenerative diseases likely to be induced by Al. |
| Anahtar Kelimeler |
| Aluminum | Epigallocatechin gallate | Neurotoxicity | NMDAR |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Environmental toxicology and pharmacology |
| Dergi ISSN | 1382-6689 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2023 |
| Cilt No | 98 |
| Sayfalar | 104061 / |
| Doi Numarası | 10.1016/j.etap.2023.104061 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S1382668923000029 |
| Atıf Sayıları | |
| SCOPUS | 1 |
