Effects of simultaneous versus post exposure epigallocatechin-3-gallate treatment on aluminum induced neurotoxicity in rat hippocampus: A multi-approach study.
Yazarlar (7)
Saziye Sezin Palabiyik-Yuceli̇K
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Prof. Dr. Naciye Dilara Zeybek Hacettepe Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Prof. Dr. Erol Akpinar Ataturk University, Faculty Of Medicine, Türkiye
Dr. Öğr. Üyesi Elham Bahador Zırh Tobb University Of Economics And Technology, Türkiye
Hande Si̇Pahi̇
Yeditepe University, Türkiye
Yeditepe University, Türkiye
Prof. Dr. Zekai Halici Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Environmental Toxicology and Pharmacology (Q1) | ||
| Dergi ISSN | 1382-6689 Dergi Bilgileri (2023) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2023 |
| Cilt / Sayı / Sayfa | 98 / 1 / 104061–0 | DOI | 10.1016/j.etap.2023.104061 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S1382668923000029 | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| Chronic aluminium(Al) exposure can affect the antioxidant and glutaminergic systems through N-methyl-D-aspartate receptors (NMDAR). This study was aimed to investigate the neurotoxic effect of Al through different mechanisms in rat hippocampus and to evaluate the protective role of epigallocatechin gallate (EGCG), a well-known antioxidant, with simultaneous administration of Al,as well as post-treatment after Al exposure.For this purpose, aluminum chloride(AlCl3) was administered simultaneously with two different EGCG doses for 8 weeks as the first part of the study.In the second part of the study, after 4 weeks of AlCl3 pre-administration, two different EGCG doses were also administered during four additional weeks as post-treatment.Al administration led to oxidative stress and increased acetylcholinesterase levels.NMDAR subunit mRNA expressions were down-regulated by Al, which was apparent in … |
| Anahtar Kelimeler |
| Aluminum | Epigallocatechin gallate | Neurotoxicity | NMDAR |
Science Direct
Effects of simultaneous versus post exposure epigallocatechin-3-gallate treatment on aluminum induced neurotoxicity in rat hippocampus: A multi-approach study.
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 7 |
| Scopus | 7 |
| Google Scholar | 8 |