The role of GRP78/ATF6/IRE1 and caspase-3/Bax/Bcl2 signaling pathways in the protective effects of gallic acid against cadmiuminduced liver damage in rats
Yazarlar (4)
Volkan Gelen Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Prof. Dr. Emin Şengül Atatürk Üniversitesi, Türkiye
Prof. Dr. Serkan Yıldırım Atatürk Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Iranian Journal of Basic Medical Sciences (Q3) | ||
| Dergi ISSN | 2008-3866 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2023 |
| Cilt / Sayı / Sayfa | 26 / 1 / 1326–1333 | DOI | 10.22038/IJBMS.2023.71343.15525 |
| Makale Linki | https://www.researchgate.net/profile/Volkan-Gelen/publication/372406232_The_role_of_GRP78ATF6IRE1_and_caspase-3BaxBcl2_signaling_pathways_in_the_protective_effects_of_gallic_acid_against_cadmium-_induced_liver_damage_in_rats/links/64b50eff8de7ed28baa | ||
| Özet |
| Objective(s): Cadmium (CD) causes widespread and severe toxic effects on various tissues. Studies have shown that apoptosis, inflammation, and endoplasmic reticulum stress play a role in organ damage caused by CD. Phenolic compounds with strong antioxidant effects are found in various fruits and vegetables. One of these compounds is Gallic acid (GA), which is found both free and hydrolyzable in grapes, pomegranate, tea, hops, and oak bark. Result of various studies show that GA has active antioxidant, anti-inflammatory, and anti-apoptotic properties. In our study, we investigated the mechanism of the protective effect of GA on CD-induced hepatotoxicity in rats. Materials and Methods In this study, 50 adult male Sprague Dawley rats weighing approximately 200–250 g were used and the rats were divided into 5 groups: Control, CD, GA50+CD, GA100+CD, and GA100. The rats were treated with GA (50 and … |
| Anahtar Kelimeler |
| Apoptosis | Cadmium | Endoplasmic reticulum - stress | Gallic acid | Hepatotoxicity | Inflammation |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 15 |
| Scopus | 18 |
| Google Scholar | 22 |