Protective effect of luteolin on acute lung injury in a rat model of sepsis
Yazarlar (8)
Doç. Dr. Demet Çelebi Atatürk Üniversitesi, Türkiye
Pelin Aydın Regional Education And Research Hospital, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Zerrin Kutlu Atatürk Üniversitesi, Türkiye
Doç. Dr. İlknur Çalık Fırat Üniversitesi, Türkiye
Prof. Dr. Zekai Halıcı Atatürk Üniversitesi, Türkiye
Dilek Bilici
Regional Education And Research Hospital, Türkiye
Regional Education And Research Hospital, Türkiye
Doç. Dr. Zafer Bayraktutan Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biotechnic and Histochemistry (Q4) | ||
| Dergi ISSN | 1052-0295 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2021 |
| Cilt / Sayı / Sayfa | 96 / 8 / 579–585 | DOI | 10.1080/10520295.2020.1846787 |
| Makale Linki | https://www.tandfonline.com/doi/abs/10.1080/10520295.2020.1846787?journalCode=ibih20 | ||
| Özet |
| We investigated the effects of luteolin (LUT) treatment on acute lung injury caused by cecal ligation and puncture (CLP) induced septic rats. We also investigated the relation between LUT and the cytokines, interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α). LUT was administered 1 h after CLP surgery. Administration of LUT reduced the glutathione level and superoxide dismutase activity in rat lung tissues. We also found significant reduction of malondialdehyde following LUT treatment. LUT administration also reduced TNF-α and IL-10 mRNA expression in lung tissue. Histopathologic investigation of lung tissue supported our biochemical and molecular findings. Administration of LUT ameliorated lung injury in CLP induced septic rats owing to its antioxidant and anti-inflammatory properties. |
| Anahtar Kelimeler |
| Antioxidants | cecal ligation | IL-10 | inflammation | luteolin | rat | sepsis | TNF-alpha |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 18 |
| Scopus | 20 |
| Google Scholar | 19 |