| Yazarlar |
Demet Çelebi
Atatürk Üniversitesi, Türkiye |
|
Pelin Aydın
|
Doç. Dr. İrfan ÇINAR
Kastamonu Üniversitesi, Türkiye |
|
Zerrin Kutlu
Atatürk Üniversitesi, Türkiye |
|
İlknur Çalık
Fırat Üniversitesi, Türkiye |
|
Zekai Halıcı
Atatürk Üniversitesi, Türkiye |
|
Dilek Bilici
|
|
Zafer Bayraktutan
Atatürk Üniversitesi, Türkiye |
| Özet |
| We investigated the effects of luteolin (LUT) treatment on acute lung injury caused by cecal ligation and puncture (CLP) induced septic rats. We also investigated the relation between LUT and the cytokines, interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α). LUT was administered 1 h after CLP surgery. Administration of LUT reduced the glutathione level and superoxide dismutase activity in rat lung tissues. We also found significant reduction of malondialdehyde following LUT treatment. LUT administration also reduced TNF-α and IL-10 mRNA expression in lung tissue. Histopathologic investigation of lung tissue supported our biochemical and molecular findings. Administration of LUT ameliorated lung injury in CLP induced septic rats owing to its antioxidant and anti-inflammatory properties. |
| Anahtar Kelimeler |
| Antioxidants | cecal ligation | IL-10 | inflammation | luteolin | rat | sepsis | TNF-alpha |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Biotechnic & Histochemistry |
| Dergi ISSN | 1052-0295 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2021 |
| Cilt No | 8 |
| Sayı | 96 |
| Sayfalar | 579 / 585 |
| Doi Numarası | 10.1080/10520295.2020.1846787 |
| Makale Linki | https://www.tandfonline.com/doi/abs/10.1080/10520295.2020.1846787?journalCode=ibih20 |
| Atıf Sayıları | |
| SCOPUS | 12 |
