Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells
Yazarlar (5)
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed Yayla Kastamonu Üniversitesi, Türkiye
Muhammet Çelik Atatürk Üniversitesi, Türkiye
Doç. Dr. Arzu Bilen Atatürk Üniversitesi, Türkiye
Doç. Dr. Zafer Bayraktutan Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(ESCI dergilerinde yayınlanan tam makale)
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| Dergi Adı | Eurasian Journal of Medicine | ||
| Dergi ISSN | 1308-8734 | ||
| Dergi Tarandığı Indeksler | ESCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2020 |
| Cilt / Sayı / Sayfa | 52 / 3 / 277–282 | DOI | 10.5152/eurasianjmed.2020.20033 |
| Makale Linki | https://www.eajm.org/en/role-of-endothelin-1-on-proliferation-and-migration-of-human-mcf-7-cells-133297 | ||
| Özet |
| Objective The aim of this study was to explore the role of endothelin 1 (ET-1) in human breast cancer proliferation and migration and antagonism of endothelin receptor A (ETAR) and endothelin receptor B (ETBR) by using the non-selective dual ETA/ETB receptor antagonist bosentan and determine its anti-proliferative, anti-metastatic, and apoptotic effects demonstrated by nuclear factor kappa B (NF-kB), vascular endothelial growth factor (VEGF), Caspase 3 and Caspase 9 expression on endothelin-induced proliferation of MCF-7 cell line in vitro. Materials and Methods A total of 8,000 cells were seeded into e-plates 24 hours after the cells were incubated with or without 10-4 M BOS (1 hour before ET-1 treatment); 10-7, 10-8, and 10-9 M ET-1 for 1–4 days. Results Whether ET-1 is present or not in the tumor area, bosentan exerts anti-proliferative effect on breast cancer. However, ET-1 and bosentan group showed … |
| Anahtar Kelimeler |
| Bosentan | Cancer | ET-1 | MCF-7 | Metastasis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 8 |
| Scopus | 8 |
| Google Scholar | 10 |