| Yazarlar |
Doğan Ge
|
|
Zekai Halıcı
Atatürk Üniversitesi, Türkiye |
|
Emre Karakuş
Türkiye |
|
Burak Erdemci
Atatürk Üniversitesi, Türkiye |
|
Akgün Alsaran
Türkiye |
Doç. Dr. İrfan ÇINAR
Kafkas Üniversitesi, Türkiye |
| Özet |
| Background: Radiotherapy is a commonly used treatment modality in head and neck cancer; however, it also negatively affects healthy structures. Direct damage to oral soft and hard tissue frequently occurs with radiotherapy. In this study, we aimed to evaluate the effect of radiotherapy on bone surrounding titanium dental implants via biomechanical and molecular methods. Materials and methods: Fifty-four implants were inserted in the left tibiae of 18 adult male New Zealand rabbits (3 implants in each rabbit). After 4 weeks of the implant surgery, the left tibiae of 12 rabbits were subjected to a single dose of irradiation (15 Gy or 30 Gy). Four weeks after the irradiation, rabbits were sacrificed and removal torque test was done for the biomechanical evaluation. Bone morphogenetic protein-2 (Bmp-2) and fibroblast growth factor-2 (Fgf-2) expression analyses were performed with Real-time PCR. Statistical analysis was done using SPSS. Results: The control group showed significantly higher removal torque value than the 15 and 30 Gy irradiation groups, and the 15 Gy irradiation group had higher removal torque value than the 30 Gy irradiation group (p <.001). The 15 Gy and 30 Gy irradiation groups had significantly lower Bmp-2 and Fgf-2 mRNA expressions than the control group (p <.001). In addition, the 30 Gy irradiation group had significantly lower Bmp-2 (p <.01) and Fgf-2 mRNA expressions (p <.001) than the 15 Gy group. Conclusion: Radiotherapy with 15 and 30 Gy doses can adversely affect osseointegration of implants by reducing the quality of bone and impairing the bone-to-implant contact. The mechanism of action seems to be related to alterations in Bmp-2 and Fgf-2 mRNA expressions. |
| Anahtar Kelimeler |
| dental | experimental study | implant | Radiation |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | ACTA ODONTOLOGICA SCANDINAVICA |
| Dergi ISSN | 0001-6357 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2018 |
| Cilt No | 76 |
| Sayı | 2 |
| Sayfalar | 130 / 134 |
| Doi Numarası | 10.1080/00016357.2017.1392601 |
| Makale Linki | https://www.tandfonline.com/doi/full/10.1080/00016357.2017.1392601 |
| Atıf Sayıları | |
| WoS | 3 |
| SCOPUS | 2 |
| Google Scholar | 5 |
