5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues
Yazarlar (6)
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Busra Sirin Ataturk University, Faculty Of Medicine, Türkiye
Prof. Dr. Zekai Halici Ataturk University, Faculty Of Medicine, Türkiye
Saziye Sezin Palabiyik-Yucelik Atatürk Üniversitesi, Türkiye
Erol Akpinar Ataturk University, Faculty Of Medicine, Türkiye
Prof. Dr. Elif Cadirci Ataturk University, Faculty Of Medicine, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Naunyn Schmiedeberg S Archives of Pharmacology (Q3) | ||
| Dergi ISSN | 0028-1298 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2021 |
| Cilt / Sayı / Sayfa | 394 / 6 / 1205–1213 | DOI | 10.1007/s00210-021-02051-z |
| Makale Linki | https://pubmed.ncbi.nlm.nih.gov/33528589/ | ||
| Özet |
| Prostate cancer (PCa) is one of the most common types of cancer seen among men worldwide. Previous studies have demonstrated that serotonin regulates cell proliferation, migration, and invasion in vitro; the presence of 5-HT receptors in cancer cells; and the role of serotonin in tumor development. The most recently discovered of these receptors is 5-HT7 but also least characterized receptors of serotonin. The aim of this study is to investigate the existence and possible role of 5-HT7 receptors in healthy and cancerous prostate tissues and also investigate effects of receptor agonists and antagonists on PC-3 cells to evaluate potential therapeutic effects. PC-3 cells were cultured and effects of 5-HT7 receptor agonist (LP-44) and antagonist (SB-269970) were evaluated on these cells. After proliferation analyses, relative expression of apoptotic markers and 5-HT7 receptor mRNA expression levels were determined … |
| Anahtar Kelimeler |
| 5-HT7 receptors | Apoptosis | LP-44 | Prostate cancer | SB-269970 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 22 |
| Scopus | 22 |
| Google Scholar | 27 |