Evaluation of the protective effects of gossypin for ischemia/reperfusion injury in ovary tissue
Yazarlar (4)
Doç. Dr. Büşra Dincer Erzincan Binali Yıldırım Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed Yayla Kafkas Üniversitesi, Türkiye
Erdem Toktay Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Obstetrics and Gynaecology Research (Q4) | ||
| Dergi ISSN | 1341-8076 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2022 |
| Cilt / Sayı / Sayfa | 48 / 3 / 748–756 | DOI | 10.1111/jog.15127 |
| Makale Linki | https://obgyn.onlinelibrary.wiley.com/doi/10.1111/jog.15127 | ||
| Özet |
| Aim Ovarian ischemia–reperfusion (I/R) injury is a serious gynecological condition that affects women of reproductive age and reduces ovarian reserve. Management of I/R injury with detorsion causes reperfusion damage, in which oxidative stress plays a central role. This study aimed to investigate whether the gossypin (GOS) with antioxidant properties, a flavonoid, has beneficial effects on the biochemical, molecular, and histopathological aspects of ovarian I/R injury. Methods Thirty‐three female Balb/c mice were randomly divided into five groups as follows: Healthy (Sham‐operated control group), I/R (IR group), I/R + GOS 5 (I/R with GOS 5 mg/kg), I/R + GOS 10 (I/R with GOS 10 mg/kg), and I/R + GOS 20 (I/R with GOS 20 mg/kg). This was followed by 3 h of ischemia and subsequent reperfusion for 3 h after detorsion was exposed. GOS was injected 2 h before reperfusion. Results IL‐1β, IL‐6, TNF‐α … |
| Anahtar Kelimeler |
| gossypin | inflammation | ischemia–reperfusion | ovary | oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 12 |
| Scopus | 12 |
| Google Scholar | 16 |