Epigallocatechin-3-gallate (EGCG) exert therapeutic effect on acute inflammatory otitis media in rats
Yazarlar (7)
Prof. Dr. Zülküf Kaya Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed Yayla Kafkas Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kafkas Üniversitesi, Türkiye
Nihal Efe Atila
Erzurum Regional Training And Research Hospital, Türkiye
Erzurum Regional Training And Research Hospital, Türkiye
Prof. Dr. Sevilay Ozmen Ataturk University, Faculty Of Medicine, Türkiye
Doç. Dr. Zafer Bayraktutan Atatürk Üniversitesi, Türkiye
Dilek Bilici
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Pediatric Otorhinolaryngology (Q3) | ||
| Dergi ISSN | 0165-5876 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2019 |
| Cilt / Sayı / Sayfa | 124 / 1 / 106–110 | DOI | 10.1016/j.ijporl.2019.05.012 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0165587619302277 | ||
| Özet |
| IntroductionThat EGCG has strong antioxidant and anti-inflammatory activities as well as antibacterial activity against many streptococcus species suggests that it may be beneficial in the treatment of AOM. Objective: Aim of the study is to reveal the molecular and biochemical effects of EGCG on LPS induced otitis media in rats.MethodsForty-two male albino Wistar rats were randomly divided into 7 groups. Inflammation was induced by administrating 50 μL of 1 mg/ml lipopolysaccharide (LPS). EGCG used 50 and 100 mg/kg/day and combined penicillin G (PENG) 48 h after LPS injection.ResultsThe combined EGCG 50 and PENG group and the group with EGCG 50 alone showed the best anti-inflammatory effect on LPS-induced AOM. TNF-α and IL-1β gene expression significantly down regulated EGCG 50 and combined with PENG compared to the otitis media group. The combination of PenG and EGCG 50 … |
| Anahtar Kelimeler |
| EGCG | Inflammation | LPS | Otitis media | Rat |
Science Direct
Epigallocatechin-3-gallate (EGCG) exert therapeutic effect on acute inflammatory otitis media in rats
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 17 |
| Scopus | 20 |
| Google Scholar | 24 |