Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats
Yazarlar (7)
Doç. Dr. İrfan ÇINAR Kafkas Üniversitesi, Türkiye
Busra Sirin Ataturk University, Faculty Of Medicine, Türkiye
Dr. Öğr. Üyesi Pelin Aydin Erzurum Regional Training And Research Hospital, Türkiye
Erdem Toktay Ataturk University, Faculty Of Medicine, Türkiye
Prof. Dr. Elif Cadirci Ataturk University, Faculty Of Medicine, Türkiye
Iclal Halici Ataturk University, Faculty Of Medicine, Türkiye
Prof. Dr. Zekai Halici Ataturk University, Faculty Of Medicine, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Life Sciences (Q2) | ||
| Dergi ISSN | 0024-3205 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2019 |
| Cilt / Sayı / Sayfa | 221 / 1 / 327–334 | DOI | 10.1016/j.lfs.2019.02.039 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0024320519301298 | ||
| Özet |
| AimsSepsis is a complex pathophysiological event involving systemic inflammatory response syndrome, multiple organ dysfunction syndrome and tissue damage such as acute lung injury (ALI). Although many new mechanisms are being investigated to enlighten the pathophysiology of sepsis, there is no effective treatment protocol yet. Antioxidant, antibacterial and antiinflammatory effects of gossypin (GOS)-like flavonoids have been shown and we have hypothesized that GOS have roles in sepsis induced inflammation of lungs.Main methodsCecal ligation and puncture (CLP) induced sepsis model was induced in rats. Effects of GOS on oxidative stress, histopathology, nuclear factor kappa B (NF-κB), IL-6 positivity and NLRP3, HMGβ1, TNF-α, NF-κB, IL-1β mRNA expression levels were evaluated in lung tissues of the septic rats.Key findingsGOS 20 (20 mg/kg) administration to septic rats decreased oxidative … |
| Anahtar Kelimeler |
| CLP | Gossypin | HMGβ1 | Lung injury | NF-κB | NLRP3 |
Science Direct
Ameliorative effect of gossypin against acute lung injury in experimental sepsis model of rats
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 69 |
| Scopus | 71 |
| Google Scholar | 97 |