The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions
Yazarlar (5)
Rüstem Anıl Uğan Atatürk Üniversitesi, Türkiye
Prof. Dr. Elif Çadırcı Atatürk Üniversitesi, Türkiye
Prof. Dr. Zekai Halıcı Atatürk Üniversitesi, Türkiye
Erdem Toktay Kafkas Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kafkas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | European Journal of Pharmacology | ||
| Dergi ISSN | 0014-2999 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2018 |
| Cilt / Sayı / Sayfa | 818 / 1 / 457–469 | DOI | 10.1016/j.ejphar.2017.11.011 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0014299917307367 | ||
| Özet |
| This study aimed to investigate the potential role of urotensin-II receptors in sepsis-induced lung injury in diabetic mice using urotensin-II receptor agonists and antagonists. A total of 110 male CD1 mice were used in this study. Diabetes was induced by 200 mg/kg streptozotocin. One month after diabetes induction, the cecal ligation and puncture-induced polymicrobial sepsis model was applied in the diabetic and non-diabetic mice. Low and high doses of human urotensin-II agonist (HU-II) and antagonist (palosuran) were administered one hour after sepsis induction. HU-II administration was repeated in two-hour intervals. Blood and tissue samples were collected at 6 and 12H after sepsis induction for biochemical, molecular, and histopathologic examinations. Regarding to the lungs mRNA expression and immunohistochemistry results of TNF-α, IL1 β, IL6, and NF-κ B, it was observed that cytokine levels … |
| Anahtar Kelimeler |
| Diabetes | Lung | Mice | Palosuran | Sepsis | Urotensin-II |
Science Direct
The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 31 |
| Scopus | 32 |
| Google Scholar | 41 |