The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells
Yazarlar (9)
Murat Karameşe Kafkas Üniversitesi, Türkiye
Bülent Güvendi Recep Tayyip Erdoğan Üniversitesi, Türkiye
Selina Aksak Karameşe Kafkas Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kafkas Üniversitesi, Türkiye
Serpil Can Kafkas Üniversitesi, Türkiye
Doç. Dr. Hüseyin Serkan Erol Atatürk Üniversitesi, Türkiye
Hakan Aydın Atatürk Üniversitesi, Türkiye
Volkan Gelen Kafkas Üniversitesi, Türkiye
Emre Karakuş Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Iranian Journal of Basic Medical Sciences | ||
| Dergi ISSN | 2008-3866 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Cilt / Sayı / Sayfa | 19 / 5 / 483–489 | DOI | – |
| Özet |
| Objective(s): In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellular carcinoma cell line Hep3B was chosen as a model for investigation of LPS toxicity and the effect of EGCG on LPS-exposed cells. Materials and Methods The Hep3B human hepatoma cells were used for this study. The cytotoxic effects of chemicals (EGCG and LPS), AST and ALT levels, SOD and CAT activities, GSH-Px level and TNF-alpha and IL-6 levels were detected by using different biochemical and molecular methods. LPS and EGCG were applied to cells at various times and doses. Results The highest … |
| Anahtar Kelimeler |
| Cytokines | Epigallocatechin gallate | Hep3B | Lipopolysaccharide | Oxidative stress |
