Biochemical and histologic study of lethal cisplatin nephrotoxicity prevention by mirtazapine
Yazarlar (8)
Mustafa Talip Şener Atatürk Üniversitesi, Türkiye
Ebru Şener Atatürk Üniversitesi, Türkiye
Adem Tok Erzurum Regional Education And Research Hospital, Türkiye
Beyzagül Polat Atatürk Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kafkas Üniversitesi, Türkiye
Prof. Dr. Harun Polat Ataturk University, Faculty Of Medicine, Türkiye
Fatih Akçay Ataturk University, Faculty Of Medicine, Türkiye
Halis Süleyman Erzincan Binali Yıldırım Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Pharmacological Reports | ||
| Dergi ISSN | 2299-5684 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2012 |
| Cilt / Sayı / Sayfa | 64 / 3 / 594–602 | DOI | 10.1016/S1734-1140(12)70855-1 |
| Makale Linki | https://link.springer.com/10.1016/S1734-1140(12)70855-1 | ||
| Özet |
| BackgroundCisplatin is a platinum derivative frequently used in the chemotherapy of different solid tumors. This biochemical and histologic study investigated a possible protective effect of mirtazapine with regard to cisplatin-induced nephrotoxicity in the rat.MethodsThe animals were divided into 4 groups: 15 mg/kg mirtazapine+ 10 mg/kg cisplatin, 30 mg/kg mirtazapine+ 10 mg/kg cisplatin, only 10 mg/kg cisplatin and negative control (healthy) group. During 14 days, the treatment and treated control group took drugs, while the healthy animals were given distilled water on the same schedule. All animals were sacrificed by high-dose anesthesia at the end of the 14 days of treatment; their kidneys were removed and subjected to histologic and biochemical study.ResultsIn both of the doses we used, mirtazapine decreased the levels of malondialdehyde, creatinine, blood urea nitrogen and myeloperoxidase activity … |
| Anahtar Kelimeler |
| Cisplatin | Mirtazapine | Oxidant/antioxidant parameters | Rat |
Science Direct
Biochemical and histologic study of lethal cisplatin nephrotoxicity prevention by mirtazapine
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 32 |
| Scopus | 36 |
| Google Scholar | 54 |