In Vivo and In Vitro Cardioprotective Effect of Gossypin Against Isoproterenol-Induced Myocardial Infarction Injury
Yazarlar (7)
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Muhammed Yayla Kafkas Üniversitesi, Türkiye
Taha Tavacı Ataturk University, Faculty Of Medicine, Türkiye
Erdem Toktay Kafkas Üniversitesi, Türkiye
Rüstem Anıl Uğan Atatürk Üniversitesi, Türkiye
Pınar Bayram Kafkas Üniversitesi, Türkiye
Hamza Halıcı Ataturk University, Faculty Of Medicine, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Cardiovascular Toxicology (Q2) | ||
| Dergi ISSN | 1530-7905 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2022 |
| Cilt / Sayı / Sayfa | 22 / 1 / 52–62 | DOI | 10.1007/s12012-021-09698-3 |
| Makale Linki | https://link.springer.com/10.1007/s12012-021-09698-3 | ||
| Özet |
| The aim of the study was to examine the protective effects and possible mechanism of gossypin against isoproterenol (ISO)-mediated myocardial damage in vivo and H9c2 cell damage in vitro. H9c2 cells were categorized into five groups. Viability was evaluated with MTT and LDH release in H9c2 cells. Apoptotic parameter analysis was performed with cytochrome c (Cyt-c), caspase-3 (CASP-3), and BCL2/Bax mRNA expression levels. In vivo, gossypin was administered orally to mice at doses of 5, 10, and 20 mg/kg for 7 days. ISO groups were injected with isoproterenol (150 mg/kg) subcutaneously (on 8th and 9th) for 2 days. Afterward, lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB) levels and Troponin-I (Tn-I) amount from their serum, oxidative stress parameters superoxide dismutase (SOD) activity, glutathione (GSH) and malondialdehyde (MDA) levels, and tumor necrosis factor-α (TNF-α … |
| Anahtar Kelimeler |
| Antioxidant | Cardioprotection | Gossypin | Isoproterenol | Myocardial infarction |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 37 |
| Scopus | 39 |
| Google Scholar | 46 |