Effects of tocilizumab and dexamethasone on the downregulation of proinflammatory cytokines and upregulation of antioxidants in the lungs in oleic acid-induced ARDS
Yazarlar (5)
Funda Terzi Kastamonu Üniversitesi, Türkiye
Doç. Dr. Beste DEMİRCİ Kastamonu Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Mohammad Alhilal Mardin Artuklu University, Türkiye
Doç. Dr. Hüseyin Serkan Erol Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Respiratory Research (Q1) | ||
| Dergi ISSN | 1465-9921 Dergi Bilgileri (2022) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2022 |
| Cilt / Sayı / Sayfa | 23 / 1 / 11–0 | DOI | 10.1186/s12931-022-02172-w |
| Makale Linki | https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-022-02172-w | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| BackgroundAcute respiratory distress syndrome (ARDS) is a life-threatening disease caused by the induction of inflammatory cytokines and chemokines in the lungs. There is a dearth of drug applications that can be used to prevent cytokine storms in ARDS treatment. This study was designed to investigate the effects of tocilizumab and dexamethasone on oxidative stress, antioxidant parameters, and cytokine storms in acute lung injury caused by oleic acid in rats.MethodsAdult male rats were divided into five groups: the CN (healthy rats, n = 6), OA (oleic acid administration, n = 6), OA + TCZ-2 (oleic acid and tocilizumab at 2 mg/kg, n = 6), OA + TCZ-4 (oleic acid and tocilizumab at 4 mg/kg, n = 6), and OA + DEX-10 (oleic acid and dexamethasone at 10 mg/kg, n = 6) groups. All animals were euthanized after treatment for histopathological, immunohistochemical, biochemical, PCR, and SEM analyses … |
| Anahtar Kelimeler |
| ARDS | Dexamethasone | Oleic acid | Rat | Tocilizumab |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 29 |
| Scopus | 26 |
| Google Scholar | 32 |