LP44 (4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazinehexanamide) exerts anti-ulcer effects via 5-hydroxytryptamine receptornbsp7 activation on indomethacin-induced gastric ulcers in rats
Yazarlar (8)
Doç. Dr. Ilknur Calik Firat Üniversitesi, Türkiye
Muhammed Yayla Kafkas Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Elif Cadirci Atatürk Üniversitesi, Türkiye
Prof. Dr. Abdulmecit Albayrak Atatürk Üniversitesi, Türkiye
Busra Sirin Atatürk Üniversitesi, Türkiye
Prof. Dr. Muhammet Calik Firat Üniversitesi, Türkiye
Zekai Halici Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Inflammopharmacology | ||
| Dergi ISSN | 0925-4692 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2020 |
| Cilt / Sayı / Sayfa | 28 / 4 / 893–902 | DOI | 10.1007/s10787-020-00725-3 |
| Makale Linki | https://link.springer.com/10.1007/s10787-020-00725-3 | ||
| Özet |
| AimThis study aimed to demonstrate the role of serotonin 7 receptor (5-HT7) and the effects of 5-HT7 agonists and antagonists in an indomethacin-induced gastric ulcer.Material and methodMale albino Wistar rats (n = 60) were used in the experiments. LP44 (5-HT7 agonist) and SB269970 (5-HT7 antagonist) were administered at 10 mg/kg as a pre-treatment. One hour after the drug treatments, 25 mg/kg of indomethacin (INDO) was administered to all groups except the healthy control group. Six hours after indomethacin administration, all the rats were euthanized.ResultsWe analyzed the iNOS, eNOS, and 5-HT7 receptor mRNA levels in the stomach tissue of rats by real-time PCR. 5-HT7 mRNA expression was increased in the INDO group compared to the healthy group. LP44 administration exerted a significant upregulatory effect on eNOS mRNA expression and downregulatory effects on iNOS and 5-HT7 … |
| Anahtar Kelimeler |
| 5-HT7 | eNOS | iNOS | Rat | Ulcer |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 3 |
| Google Scholar | 4 |