| Yazarlar |
Zülküf Kaya
Atatürk Üniversitesi, Türkiye |
|
Muhammed Yayla
Kafkas Üniversitesi, Türkiye |
|
Arzu Bilen
Atatürk Üniversitesi, Türkiye |
|
Nihal Efe Atilla
|
|
Sevilay Özmen
Atatürk Üniversitesi, Türkiye |
Doç. Dr. İrfan ÇINAR
Kafkas Üniversitesi, Türkiye |
|
Zafer Bayraktutan
Atatürk Üniversitesi, Türkiye |
|
Vahit Mutlu
Atatürk Üniversitesi, Türkiye |
|
Harun Ün
Ağrı İbrahim Çeçen Üniversitesi, Türkiye |
|
Erdem Toktay
Kafkas Üniversitesi, Türkiye |
| Özet |
| Objective: The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR. Materials and Methods: Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group. Results: Desloratadine administration had significantly lower nasal symptoms than the AR group, but nasal symptoms in the AR+M group were better than those in the AR+D group. The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups. Conclusion: We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of these types of drugs should be tested clinically in patients. |
| Anahtar Kelimeler |
| Allergy | Desloratadine | Misoprostol | Rat | Rhinitis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | The Eurasian Journal of Medicine |
| Dergi ISSN | 1308-8734 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | İngilizce |
| Basım Tarihi | 02-2019 |
| Cilt No | 51 |
| Sayı | 1 |
| Sayfalar | 75 / 79 |
| Doi Numarası | 10.5152/eurasianjmed.2019.19025 |
| Makale Linki | http://dx.doi.org/10.5152/eurasianjmed.2019.19025 |
| Atıf Sayıları | |
| SCOPUS | 2 |
