Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model
Yazarlar (10)
Prof. Dr. Zülküf Kaya Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed Yayla Kafkas Üniversitesi, Türkiye
Doç. Dr. Arzu Bilen Atatürk Üniversitesi, Türkiye
Nihal Efe Atilla Erzurum Training And Research Hospital, Türkiye
Prof. Dr. Sevilay Özmen Atatürk Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kafkas Üniversitesi, Türkiye
Doç. Dr. Zafer Bayraktutan Atatürk Üniversitesi, Türkiye
Vahit Mutlu Atatürk Üniversitesi, Türkiye
Harun Ün
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Erdem Toktay Kafkas Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayınlanan tam makale)
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| Dergi Adı | Eurasian Journal of Medicine | ||
| Dergi ISSN | 1308-8734 | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2019 |
| Cilt / Sayı / Sayfa | 51 / 1 / 75–79 | DOI | 10.5152/eurasianjmed.2019.19025 |
| Makale Linki | http://dx.doi.org/10.5152/eurasianjmed.2019.19025 | ||
| Özet |
| Objective The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR. Materials and Methods Twenty-five adult male rats were used and were randomly classified into five groups (n=5): healthy+saline, AR, AR and desloratadine (D)-treated group, AR and misoprostol (M)-treated group, and AR and combined-treated group. Results Desloratadine administration had significantly lower nasal symptoms than the AR group, but nasal symptoms in the AR+M group were better than those in the AR+D group. The best improvement in serum IgE levels was seen in the misoprostol alone and combination treatment groups. Conclusion We suggest that prostaglandins should be considered in the treatment of AR, and that the effects of … |
| Anahtar Kelimeler |
| Allergy | Desloratadine | Misoprostol | Rat | Rhinitis |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 4 |
| Google Scholar | 6 |