Biochemical Research of the Effects of Essential Oil Obtained from the Fruit of Myrtus communis L. on Cell Damage Associated with Lipopolysaccharide‑Induced Endotoxemia in a Human Umbilical Cord Vein Endothelial Cells
Yazarlar (5)
Zerrin Kutlu Atatürk Üniversitesi, Türkiye
Mine Gülaboğlu Atatürk Üniversitesi, Türkiye
Prof. Dr. Zekai Halıcı Atatürk Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Büşra Diyarbakır Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biochemical Genetics (Q4) | ||
| Dergi ISSN | 0006-2928 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2021 |
| Cilt / Sayı / Sayfa | 59 / 1 / 315–334 | DOI | 10.1007/s10528-020-10005-y |
| Makale Linki | https://link.springer.com/article/10.1007/s10528-020-10005-y | ||
| Özet |
| The aim of this study to investigate the potential effects of essential oils and compounds obtained from MC fruit on sepsis induced endothelial cell damage in human umbilical cord vein endothelial cells (HUVECs) at molecular and cellular levels on in vitro sepsis model. A sepsis model was induced by the application of LPS. The HUVEC treatment groups were as follows: control, LPS, MC, MC plus LPS, 1.8 cineole, 1.8 cineole plus LPS, α-pinene, α-pinene plus LPS, α-terpineol, and α-terpineol plus LPS. Following the treatments, cell proliferation was analyzed using the xCELLigence® system. The mRNA expression of various cytokines [tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and IL-6] and endothelial nitric oxide (eNOS) were determined by quantitative polymerase chain reaction (qPCR) analysis. The 1.8 cineole and α-pinene treatments at specific doses showed toxic effects on α-terpineine, although it … |
| Anahtar Kelimeler |
| 1.8 Cineole | HUVEC | LPS | Myrtus communis L | α-Pinene | α-Terpineole |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 12 |
| Scopus | 14 |
| Google Scholar | 20 |