Does daily fasting shielding kidney on hyperglycemia-related inflammatory cytokine via TNF-α, NLRP3, TGF-β1 and VCAM-1 mRNA expression
Yazarlar (10)
Doç. Dr. Arzu Bilen Ataturk University, Faculty Of Medicine, Türkiye
Doç. Dr. İlknur Çalık Firat Üniversitesi Tip Fakültesi, Türkiye
Dr. Öğr. Üyesi Muhammed Yayla Kafkas Üniversitesi, Türkiye
Doç. Dr. Büşra Dincer Erzincan Binali Yıldırım Üniversitesi, Türkiye
Taha Tavacı Ataturk University, Faculty Of Medicine, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Habip Bilen Ataturk University, Faculty Of Medicine, Türkiye
Prof. Dr. Elif Çadırcı Atatürk Üniversitesi, Türkiye
Prof. Dr. Zekai Halıcı Ataturk University, Faculty Of Medicine, Türkiye
Filiz Mercantepe Ataturk University, Faculty Of Medicine, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | International Journal of Biological Macromolecules (Q1) | ||
| Dergi ISSN | 0141-8130 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2021 |
| Cilt / Sayı / Sayfa | 190 / 1 / 911–918 | DOI | 10.1016/j.ijbiomac.2021.08.216 |
| Makale Linki | http://dx.doi.org/10.1016/j.ijbiomac.2021.08.216 | ||
| Özet |
| This study aimed to investigate the effects of blood glucose control and the kidneys' functions, depending on fasting, in the streptozotocin-induced diabetes model in rats via TNF-α, NLRP-3, TGF-β1 and VCAM-1 mRNA expression in the present study. 32 Wistar albino rats were allocated randomly into four main groups; H (Healthy, n = 6), HF (Healthy fasting, n = 6), D (Diabetes, n = 10), DF (Diabetes and fasting, n = 10). Blood glucose and HbA1c levels significantly increased in the D group compared to the healthy ones (p < 0.05). However, the fasting period significantly improved blood glucose and HbA1c levels 14 days after STZ induced diabetes in rats compared to the D group. Similar findings we obtained for serum (BUN-creatinine) and urine samples (creatinine and urea levels). STZ induced high glucose levels significantly up-regulated TNF-α, NLRP-3, TGF-β1 and VCAM-1 mRNA expression and fasting … |
| Anahtar Kelimeler |
| Diabetes | Fasting | Kidney | Rat |
Science Direct
Does daily fasting shielding kidney on hyperglycemia-related inflammatory cytokine via TNF-α, NLRP3, TGF-β1 and VCAM-1 mRNA expression
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 19 |
| Scopus | 19 |
| Google Scholar | 31 |