| Yazarlar |
Arzu Bilen
Türkiye |
|
İlknur Çalık
Türkiye |
|
Muhammed Yayla
Türkiye |
|
Büşra Dincer
Türkiye |
|
Taha Tavacı
Türkiye |
Doç. Dr. İrfan ÇINAR
Kastamonu Üniversitesi, Türkiye |
|
Habip Bilen
|
|
Elif Çadırcı
Atatürk Üniversitesi, Türkiye |
|
Zekai Halıcı
Türkiye |
|
Filiz Mercantepe
Türkiye |
| Özet |
| This study aimed to investigate the effects of blood glucose control and the kidneys' functions, depending on fasting, in the streptozotocin-induced diabetes model in rats via TNF-α, NLRP-3, TGF-β1 and VCAM-1 mRNA expression in the present study. 32 Wistar albino rats were allocated randomly into four main groups; H (Healthy, n = 6), HF (Healthy fasting, n = 6), D (Diabetes, n = 10), DF (Diabetes and fasting, n = 10). Blood glucose and HbA1c levels significantly increased in the D group compared to the healthy ones (p < 0.05). However, the fasting period significantly improved blood glucose and HbA1c levels 14 days after STZ induced diabetes in rats compared to the D group. Similar findings we obtained for serum (BUN-creatinine) and urine samples (creatinine and urea levels). STZ induced high glucose levels significantly up-regulated TNF-α, NLRP-3, TGF-β1 and VCAM-1 mRNA expression and fasting significantly decreased these parameters when compared to diabetic rats. Histopathological staining also demonstrated the protective effects of fasting on diabetic kidney tissue. In conclusion, intermittent fasting regulated blood glucose level as well as decreasing harmful effects of diabetes on kidney tissue. The fasting period significantly decreased the hyperglycemia-related inflammatory cytokine damage on kidneys and also reduced apoptosis in favor of living organisms. |
| Anahtar Kelimeler |
| Diabetes | Fasting | Kidney | Rat |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | International Journal of Biological Macromolecules |
| Dergi ISSN | 0141-8130 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2021 |
| Cilt No | 190 |
| Doi Numarası | 10.1016/j.ijbiomac.2021.08.216 |
| Makale Linki | http://dx.doi.org/10.1016/j.ijbiomac.2021.08.216 |
| Atıf Sayıları | |
| SCOPUS | 8 |
