| Yazarlar |
Mustafa Talip Şener
Atatürk Üniversitesi, Türkiye |
|
Erol Akpınar
Atatürk Üniversitesi, Türkiye |
|
Elif Çadırcı
Atatürk Üniversitesi, Türkiye |
|
Zekai Halıcı
Atatürk Üniversitesi, Türkiye |
Doç. Dr. İrfan ÇINAR
Kastamonu Üniversitesi, Türkiye |
|
Ahmet Nezih Kök
Atatürk Üniversitesi, Türkiye |
| Özet |
| This study aimed to investigate changes in postmortem urotensin II receptor (UTR) levels in brain and kidney tissues in a rat model of cardiac ischemia. The rats were divided into two groups: a control group and a cardiac ischemia-induced group. Cardiac ischemia was created by an intraperitoneal injection of a single lethal dose of isoproterenol (ISO; 850 mg/kg). Plasma UT, blood urea nitrogen, and creatinine levels were determined 0 h postmortem. Brain and kidney UTR mRNA expression levels were determined 0, 1, 3, 6, 12, 24, 48, and 72 h postmortem. The histopathological appearance of brain and kidney tissues was also evaluated. Plasma UT and plasma creatinine levels were increased in the cardiac ischemia-induced group as compared with those in the control group (P < 0.001). Ischemia resulted in histopathological changes in brain and cerebellum tissue. The morphological evaluation revealed Purkinje cell degeneration (P = 0.037) and dark neurons (P = 0.004). The UTR expression level decreased after 1 h postmortem in the brain and after 3 h postmortem in the kidneys in the cardiac ischemia-induced group as compared with that in the control group (P < 0.001). The observed changes in UTR expression levels may be valuable in clinical practice in the field of forensic medicine. These changes may be used as a marker in postmortem evaluations of sudden death caused by ischemia-induced cardiac shock. |
| Anahtar Kelimeler |
| Brain | cardiac ischemia | kidney | postmortem | urotensin II receptor expression |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayımlanan tam makale |
| Dergi Adı | J Forensic Sci Med |
| Dergi ISSN | 2349-5014 |
| Dergi Tarandığı Indeksler | Scopus |
| Makale Dili | İngilizce |
| Basım Tarihi | 03-2018 |
| Cilt No | 4 |
| Sayı | 1 |
| Sayfalar | 1 / 6 |
| Doi Numarası | 10.4103/jfsm.jfsm_75_17 |
| Makale Linki | https://www.jfsmonline.com/downloadpdf.asp?issn=2349-5014;year=2018;volume=4;issue=1;spage=1;epage=6;aulast=Sener;type=2 |
| Atıf Sayıları |
