An Investigation of Postmortem Urotensin II Receptor Levels in Brain and Kidney Tissues in a Rat Model of Cardiac Ischemia
Yazarlar (6)
Mustafa Sener
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
Prof. Dr. Erol Akpinar Atatürk Üniversitesi, Türkiye
Elif Cadirci Atatürk Üniversitesi, Türkiye
Prof. Dr. Zekai Halici Atatürk Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Atatürk Üniversitesi, Türkiye
Ahmet Kok
Atatürk Üniversitesi, Türkiye
Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Journal of Forensic Science and Medicine | ||
| Dergi ISSN | 2349-5014 Scopus Dergi | ||
| Dergi Tarandığı Indeksler | Scopus | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2018 |
| Cilt / Sayı / Sayfa | 4 / 1 / 1–6 | DOI | 10.4103/jfsm.jfsm_75_17 |
| Makale Linki | https://www.jfsmonline.com/downloadpdf.asp?issn=2349-5014;year=2018;volume=4;issue=1;spage=1;epage=6;aulast=Sener;type=2 | ||
| UAK Araştırma Alanları |
Sağlık Bilimleri
|
||
| Özet |
| This study aimed to investigate changes in postmortem urotensin II receptor (UTR) levels in brain and kidney tissues in a rat model of cardiac ischemia. The rats were divided into two groups: a control group and a cardiac ischemia-induced group. Cardiac ischemia was created by an intraperitoneal injection of a single lethal dose of isoproterenol (ISO; 850 mg/kg). Plasma UT, blood urea nitrogen, and creatinine levels were determined 0 h postmortem. Brain and kidney UTR mRNA expression levels were determined 0, 1, 3, 6, 12, 24, 48, and 72 h postmortem. The histopathological appearance of brain and kidney tissues was also evaluated. Plasma UT and plasma creatinine levels were increased in the cardiac ischemia-induced group as compared with those in the control group (P< 0.001). Ischemia resulted in histopathological changes in brain and cerebellum tissue. The morphological evaluation revealed … |
| Anahtar Kelimeler |
| Brain | cardiac ischemia | kidney | postmortem | urotensin II receptor expression |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları |