Effect of Montelukast, a Cysteinyl Leukotriene Receptor-1 Antagonist, on a Rat Model of Acute Bacterial Sinonasal Inflammation
Yazarlar (7)
Prof. Dr. Zülküf Kaya Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed Yayla Kafkas Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kafkas Üniversitesi, Türkiye
Demet Celebi Atatürk Üniversitesi, Türkiye
Erdem Toktay Kafkas Üniversitesi, Türkiye
Doç. Dr. Zafer Bayraktutan Atatürk Üniversitesi, Türkiye
Dilek Bilici
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | American Journal of Rhinology and Allergy (Q2) | ||
| Dergi ISSN | 1945-8924 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2019 |
| Cilt / Sayı / Sayfa | 33 / 5 / 559–566 | DOI | 10.1177/1945892419852576 |
| Makale Linki | https://journals.sagepub.com/doi/10.1177/1945892419852576 | ||
| Özet |
| AimThis study aimed to investigate montelukast (MONT), a leukotriene receptor antagonist, as a potential treatment protocol and/or supportive therapy against acute bacterial sinonasal inflammation by histopathological and molecular analyses.Material and MethodsA total of 30 rats were used in the study. The nasal dorsum was sterilized, and gelatin sponges were inserted into the right nasal cavities. The nostrils were then inoculated with Staphylococcus aureus (SA) for rhinosinusitis (RS) induction. Rats were treated once daily for 7 days with an injection of saline, either cefazolin sodium (CEFA) or MONT. Tissue samples were collected for examination.ResultsTo evaluate whether CEFA and MONT were able to attenuate the SA-induced nasal inflammation, we analyzed the proinflammatory cytokine levels in the nasal tissue of rats by real-time polymerase chain reaction (PCR). The inflammatory cytokines tumor … |
| Anahtar Kelimeler |
| interleukin-1 | montelukast | rat | sinonasal inflammation | Staphylococcus aureus | tumor necrosis factor-α |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 7 |
| Google Scholar | 6 |