The protective effects of carvacrol and thymol against paracetamol-induced toxicity on human hepatocellular carcinoma cell lines (HepG2)
Yazarlar (7)
S. S. Palabiyik Atatürk Üniversitesi, Türkiye
E. Karakus Atatürk Üniversitesi, Türkiye
Z. Halici Ataturk University, Faculty Of Medicine, Türkiye
E. Cadirci Ataturk University, Faculty Of Medicine, Türkiye
Y. Bayir Atatürk Üniversitesi, Türkiye
G. Ayaz Ataturk University, Faculty Of Medicine, Türkiye
Doç. Dr. İrfan ÇINAR Ataturk University, Faculty Of Medicine, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Human and Experimental Toxicology | ||
| Dergi ISSN | 0960-3271 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2016 |
| Cilt / Sayı / Sayfa | 35 / 12 / 1252–1263 | DOI | 10.1177/0960327115627688 |
| Makale Linki | https://journals.sagepub.com/doi/10.1177/0960327115627688 | ||
| Özet |
| Acetaminophen (APAP) overdose could induce liver damage and lead to acute liver failure. The treatment of APAP overdoses could be improved by new therapeutic strategies. Thymus spp., which has many beneficial effects and has been used in folk medicine, is one such potential strategy. In the present study, the hepatoprotective activity of the main constituents of Thymus spp., carvacrol and thymol, were evaluated in light of APAP-induced hepatotoxicity. We hoped to understand the hepatoprotective mechanism of these agents on the antioxidant system and pro-inflammatory cytokines in vitro. Dose-dependent effects of thymol and carvacrol (25, 50, and 100 µM) were tested on cultured HepG2 cells. N-Acetylcysteine (NAC) was tested as positive control. We showed that APAP inhibited HepG2 cell growth by inducing inflammation and oxidative stress. Incubating APAP-exposed HepG2 cells with carvacrol and … |
| Anahtar Kelimeler |
| Acetaminophen toxicity | carvacrol | HepG2-cultured cell | IL-1β | thymol | TNF-α |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 70 |
| Google Scholar | 92 |