A new update for radiocontrast-induced nephropathy aggravated with glycerol in rats: the protective potential of epigallocatechin-3-gallate
Yazarlar (8)
Şaziye Sezin Palabıyık Atatürk Üniversitesi, Türkiye
Doç. Dr. Büşra Dinçer Ataturk University, Faculty Of Medicine, Türkiye
Prof. Dr. Elif Çadırcı Atatürk Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kafkas Üniversitesi, Türkiye
Prof. Dr. Cemal Gündoğdu Ataturk University, Faculty Of Medicine, Türkiye
Beyzagül Polat Atatürk Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed Yayla Kafkas Üniversitesi, Türkiye
Prof. Dr. Zekai Halıcı Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Renal Failure | ||
| Dergi ISSN | 0886-022X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Cilt / Sayı / Sayfa | 39 / 1 / 314–322 | DOI | 10.1080/0886022X.2016.1277245 |
| Makale Linki | https://doi.org/10.1080/0886022x.2016.1277245 | ||
| Özet |
| Contrast media (CM) is known to have nephrotoxic adverse effects. Epigallocatechin-3-gallate (EGCG) is the most abundant and active catechin in green tea, and has strong antioxidant and anti-inflammatory properties. This study investigated whether EGCG can reduce contrast-induced nephrotoxicity (CIN), alone or with glycerol (GLY)-induced renal damage, and to understand its mechanisms of protection against toxicity, using models of GLY and CIN in rats. The rats were separated into eight groups (n = 6 in each), as follows: Healthy, GLY, CM, GLY + CM, CM + EGCG 50 mg/kg (po), GLY + CM + EGCG 50 mg/kg (po), CM + EGCG 100 mg/kg (po), and GLY + CM + EGCG 100 mg/kg (po). Both doses of EGCG protected against CM-induced renal dysfunction, as measured by serum creatinine and blood urea nitrogen (BUN). In addition, EGCG treatment markedly improved CIN-induced … |
| Anahtar Kelimeler |
| Contrast media | EGCG | Nephrotoxicity | Rat |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 15 |
| Scopus | 18 |
| Google Scholar | 21 |