| Yazarlar |
Şaziye Sezin Palabıyık
Atatürk Üniversitesi, Türkiye |
|
Büşra Dinçer
|
|
Elif Çadırcı
Atatürk Üniversitesi, Türkiye |
Doç. Dr. İrfan ÇINAR
Kafkas Üniversitesi, Türkiye |
|
Cemal Gündoğdu
|
|
Beyzagül Polat
Atatürk Üniversitesi, Türkiye |
|
Muhammed Yayla
Kafkas Üniversitesi, Türkiye |
|
Zekai Halıcı
Atatürk Üniversitesi, Türkiye |
| Özet |
| Contrast media (CM) is known to have nephrotoxic adverse effects. Epigallocatechin-3-gallate (EGCG) is the most abundant and active catechin in green tea, and has strong antioxidant and anti-inflammatory properties. This study investigated whether EGCG can reduce contrast-induced nephrotoxicity (CIN), alone or with glycerol (GLY)-induced renal damage, and to understand its mechanisms of protection against toxicity, using models of GLY and CIN in rats. The rats were separated into eight groups (n=6 in each), as follows: Healthy, GLY, CM, GLY+CM, CM+EGCG 50mg/kg (po), GLY+CM+EGCG 50mg/kg (po), CM+EGCG 100mg/kg (po), and GLY+CM+EGCG 100mg/kg (po). Both doses of EGCG protected against CM-induced renal dysfunction, as measured by serum creatinine and blood urea nitrogen (BUN). In addition, EGCG treatment markedly improved CIN-induced oxidative stress, and resulted in a significant down-regulatory effect on tumor necrosis factor (TNF)-α and nuclear factor (NF)-κB mRNA expression. Moreover, histopathological analysis showed that EGCG also attenuated CM-induced kidney damage. Considering the potential clinical use of CM and the numerous health benefits of EGCG, this study showed the protective role of multi-dose EGCG treatment on CIN and GLY-aggravated CIN through different mechanisms. |
| Anahtar Kelimeler |
| Contrast media | EGCG | Nephrotoxicity | Rat |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | RENAL FAILURE |
| Dergi ISSN | 0886-022X |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2017 |
| Cilt No | 39 |
| Sayı | 1 |
| Sayfalar | 314 / 322 |
| Doi Numarası | 10.1080/0886022X.2016.1277245 |
| Atıf Sayıları | |
| SCOPUS | 16 |
