The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction
Yazarlar (5)
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Z. Halici Atatürk Üniversitesi, Türkiye
B. Dincer Erzincan Binali Yıldırım Üniversitesi, Türkiye
B. Sirin Atatürk Üniversitesi, Türkiye
E. Cadirci Atatürk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Human and Experimental Toxicology | ||
| Dergi ISSN | 0960-3271 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2020 |
| Cilt / Sayı / Sayfa | 39 / 8 / 1005–1018 | DOI | 10.1177/0960327120916821 |
| Makale Linki | https://journals.sagepub.com/doi/10.1177/0960327120916821 | ||
| Özet |
| The presence of 5-HT7r’s in both human and rat cardiovascular and immune tissues and their contribution to inflammatory conditions prompted us to hypothesize that these receptors contribute in acute myocardial infarction (MI) with underlying chronic endothelial dysfunction. We investigated the role of 5-HT7 receptors on heart tissue that damaged by isoproterenol (ISO)-induced MI in rats with high-fat diet (HFD). In vitro and in vivo effects of 5-HT7r agonist (LP44) and antagonist (SB269970) have been investigated on the H9C2 cell line and rats, respectively. For in vivo analyses, rats were fed with HFD for 8 weeks and after this period ISO-induced MI model has been applied to rat. To investigate the role of 5-HT7r’s, two different doses of LP44 and SB269970 were evaluated and compared with standard hypolipidemic agent, atorvastatin. In vitro studies showed that LP44 has protective and proliferative effects on rat … |
| Anahtar Kelimeler |
| 5-HT7 receptor | hyperlipidemia | LP44 | myocardial infarction | SB269970 | serotonin |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 16 |
| Scopus | 17 |
| Google Scholar | 23 |