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Evaluation of Endothelial Dysfunction in Bipolar Affective Disorders: Serum Endocan and Urotensin-II Levels       
Yazarlar
Elif Oral
İzmir Katip Çelebi Üniversitesi, Türkiye
Zekai Halıcı
Atatürk Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR
Kafkas Üniversitesi, Türkiye
Elıf Ozcan
Zerrin Kutlu
Atatürk Üniversitesi, Türkiye
Özet
Objective: This study investigated changes in urotensin-II (U-II) and endocan levels which can be used as an early biological marker of endothelial injury in the episode and remission phases of bipolar affective disorder (BAD). Methods: We compared endocan and U-II levels, which has been shown to be closely associated with neurotransmitter systems in addition to continuity of endothelial structure and inflammatory response, in patients with BAD in remission for at least one year (n=42) and in patients still in manic or depressive episodes (n=16) with healthy controls (n=30). Results: Both endocan and U-II levels were significantly higher in the bipolar patients than in the controls. Endocan and U-II levels were also significantly correlated with one another (p =0.000, r=0.833). Both endocan (p =0.000) and U-II levels (p =0.000) were significantly higher in the bipolar attack group compared to the subjects in remission, and in the remission group compared to the controls. Conclusion: In this study we determined significantly higher endocan and U-II levels in BAD compared to the controls, while serum endocan and U-II levels of patients undergoing attacks were also significantly higher than those of the controls and also those of patients in remission.
Anahtar Kelimeler
Bipolar disorder | Endocan | Endothelial injury | Urotensins
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
Dergi ISSN 1738-1088
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q3
Makale Dili İngilizce
Basım Tarihi 05-2019
Cilt No 17
Sayı 2
Sayfalar 211 / 221
Doi Numarası 10.9758/cpn.2019.17.2.211
Makale Linki http://www.cpn.or.kr/journal/view.html?doi=10.9758/cpn.2019.17.2.211