img
Effects of zinc supplementation on metallothionein levels in ischemic renal tissue       
Yazarlar
Dr. Öğr. Üyesi Betül YAZĞAN
Adıyaman Üniversitesi, Türkiye
Abdulkerim Kasım Baltacı
Selçuk Üniversitesi, Türkiye
Rasim Moğulkoç
Selçuk Üniversitesi, Türkiye
Mustafa Cihat Avunduk
Necmettin Erbakan Üniversitesi, Türkiye
Özet
We investigated how zinc (Zn) supplementation affects metallothionein levels in the cortex and medulla of ischemic renal tissue of rats. We used adult male rats divided into four groups: group 1, untreated control; group 2, sham-operated; group 3, ischemia-reperfusion; group 4, ischemia-reperfusion + 5 g/kg Zn. Renal tissue was analyzed using immunostaining of rat metallothionein. Cells stained with metallothionein were counted and their percentage was calculated. We found that the Zn supplemented ischemia and reperfusion group exhibited a greater percentage of cells stained strongly for metallothionein in the renal cortex than all other groups. In the renal medulla, percentages of weak staining for metallothionein in the control and ischemia and reperfusion groups were greater than those in the sham and Zn-supplemented ischemia/reperfusion groups. Our findings indicate that the main effect of Zn in the renal tissue occurs in the cortex, while metallothionein synthesis in the renal medulla is unaffected.
Anahtar Kelimeler
ischemia | kidney | metallothionein | rat | renal tissue | reperfusion | supplementation | zinc
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı BIOTECHNIC & HISTOCHEMISTRY
Dergi ISSN 1052-0295
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q3
Makale Dili İngilizce
Basım Tarihi 05-2020
Cilt No 95
Sayı 4
Sayfalar 285 / 296
Doi Numarası 10.1080/10520295.2019.1691264
Makale Linki https://doi.org/10.1080/10520295.2019.1691264