Raloxifene and Tamoxifen Reduce PARP Activity, Cytokine and Oxidative Stress Levels in the Brain and Blood of Ovariectomized Rats
Yazarlar (4)
Dr. Öğr. Üyesi Betül YAZĞAN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Yener YAZĞAN Kastamonu Üniversitesi, Türkiye
İshak Suat Övey Alanya Alaaddin Keykubat Üniversitesi, Türkiye
Mustafa Nazıroğlu Süleyman Demirel Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Neuroscience (Q3) | ||
| Dergi ISSN | 0895-8696 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 10-2016 |
| Cilt / Sayı / Sayfa | 60 / 2 / 214–222 | DOI | 10.1007/s12031-016-0785-9 |
| Makale Linki | https://doi.org/10.1007/s12031-016-0785-9 | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| It is well known that 17β-estradiol (E2) has an antioxidant role on neurological systems in the brain. Raloxifene (RLX) and tamoxifen (TMX) are selective estrogen receptor modulators. An E2 deficiency stimulates mitochondrial functions for promoting apoptosis and increasing reactive oxygen species (ROS) production. However, RLX and TMX may reduce the mitochondrial ROS production via their antioxidant properties in the brain and erythrocytes of ovariectomized (OVX) rats. We aimed to investigate the effects of E2, RLX, and TMX on oxidative stress, apoptosis, and cytokine production in the brain and erythrocytes of OVX rats.Forty female rats were divided into five groups. The first group was used as a control group. The second group was the OVX group. The third, fourth, and fifth groups were OVX + E2, OVX + TMX, and OVX + RLX groups, respectively. E2, TMX, and RLX were given subcutaneously to … |
| Anahtar Kelimeler |
| Apoptosis | Brain | Cytokine | Oxidative stress | Selective estrogen receptor modulators |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 24 |
| Scopus | 26 |
| Google Scholar | 34 |