Effect of zinc sulfate supplementation on metallothionein levels in rat heart tissue with induced ischemia-reperfusion injury
Yazarlar (5)
Dr. Öğr. Üyesi Betül YAZĞAN Kastamonu Üniversitesi, Türkiye
Abdulkerim Kasım Baltacı Selçuk Üniversitesi, Türkiye
Rasim Moğulkoç Selçuk Üniversitesi, Türkiye
Mustafa Cihat Avunduk Necmettin Erbakan Üniversitesi, Türkiye
Engin Şahna Fırat Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SCOPUS dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Biointerface Research in Applied Chemistry | ||
| Dergi ISSN | 2069-5837 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | Scopus | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2018 |
| Cilt / Sayı / Sayfa | 8 / 3 / 3193–3196 | DOI | – |
| Makale Linki | https://biointerfaceresearch.com/?page_id=2421 | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| Metallothioneins are remarkable proteins with regard to their role in the regulation of intracellular zinc balance and mediation of the physiological effects of zinc, as well as their antioxidant effects. The objective of the present study is to examine how zinc supplementation impacts metallothionein levels in ischemia-reperfusion injury in rats. The study involved heart tissues obtained from 30 Wistar-Albino adult male rats already used in another project. Experimental animals were equally divided into three groups as follows: Group 1: Control (H-Cont); Group 2: Heart Ischemia/Reperfusion (H-I/R); and Group 3: Zinc supplemented Ischemia/Reperfusion (H/Zn-I/R). Cardiac ischemia-reperfusion procedures were carried out under general anesthesia. In the zinc-supplemented cardiac I/R group (Group 3), the animals were supplemented with 5 mg/kg/day intraperitoneal (i.p.) zinc sulfate per rat for 21 days. At the end of the … |
| Anahtar Kelimeler |
| Cardiac ischemia-reperfusion | Metallothionein | Rat | Zinc supplementation |
