In Vitro Osteogenic Differentiation of Rat Mesenchymal Stem Cells in a Microgravity Bioreactor
Yazarlar (4)
Aysel Koç Ankara Üniversitesi, Türkiye
Doç. Dr. Nuray EMİN Ankara Üniversitesi, Türkiye
A. Eser Elçin Ankara Üniversitesi, Türkiye
Y. Murat Elçin Ankara Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Bioactive and Compatible Polymers (Q3) | ||
| Dergi ISSN | 0883-9115 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 05-2008 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-05-2008 |
| Cilt / Sayı / Sayfa | 23 / 3 / 244–261 | DOI | 10.1177/0883911508091828 |
| Makale Linki | http://dx.doi.org/10.1177/0883911508091828 | ||
| Özet |
| Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the ability to differentiate into osteoblasts, chondroblasts, myocytes, and adipocytes. They have potential for bone tissue engineering by the utilization of in vitro expanded cells with osteogenic capacity and their delivery to the appropriate sites via biomaterial scaffolds. The objective was to evaluate the potential of rat bone marrow MSCs to form 3D bone-like tissue by the use of mineralized poly(DL-lactic-co-glycolic acid) (PLGA) foam and osteoinductive medium under rotating culture conditions. PLGA foams were prepared by solvent casting and particulate leaching, then mineralized by incubating in simulated body fluid. MSCs isolated from the bone marrow of young Wistar rats were expanded and seeded on the mineralized scaffolds. The cell-polymer constructs were then cultured in a slow turning lateral vessel-type rotating bioreactor for 4 … |
| Anahtar Kelimeler |
| Bone tissue engineering | Mesencyhmal stem cells | Microgravity bioreactor | Mineralization | MSCs | Osteogenic differentiation | PLGA | Stroma |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 31 |
| Scopus | 38 |
| Google Scholar | 51 |