| Yazarlar (7) |
Dr. Öğr. Üyesi Betül YAZĞAN
Adıyaman Üniversitesi, Türkiye |
Taylan Şengal Bağcı
|
|
Mehmet Öz
|
|
Hülagu Barışkaner
|
|
Serdar Gergerlioğlu
|
|
Gülsüm Tekin
|
|
Ceyhan Uğurluoğlu
Selçuk Üniversitesi, Türkiye |
| Özet |
| Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders in elderly people. It leads to the progressive loss of mental and behavioural and cognitive impairments. Recent studies showed that antioxidants may have important roles as a neuroprotective for AD. In this study, we aimed to investigate biochemical and histopathological changes in the brain tissue, along with depression and anxiety stress test, and effects of CoQ10 prophylactic treatment on these parameters in the model of experimental dementia of Alzheimer’s type in rats Rats were divided randomizedly four groups. CoQ10 (12 mg/kg/day; i.p.) were administered to the Lesion and CoQ10 (L-C) group for 3 weeks. On 22th day, rats were injected in bilateral intracerebroventricular streptozotocin (ICV-STZ) (3 mg/kg). The same experimental procedure were applied to other groups (only vehicle administered sham group (S), only ICV-STZ administered lesion group (L) and CoQ10 pretreatment sham group (S-C)). After two weeks, rats were tested by the open field and the forced swim tests. The brain tissues were analyzed for levels of AChE enzyme activity and total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSİ). Neuron damage and iNOS were showed histochemically. As a result, we demonstrated that depression and anxiety like behaviors were increased in the L group. The model of experimental dementia of Alzheimer’s type (group L-C) was decreased by the administration of CoQ10. Furthermore the AChE enzyme activity levels were measured in the cerebral cortex area. It was found significantly increased (p<0,05) in the L … |
| Anahtar Kelimeler |
| Bildiri Türü | Tebliğ/Bildiri |
| Bildiri Alt Türü | Özet Metin Olarak Yayınlanan Tebliğ (Uluslararası Kongre/Sempozyum) |
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum |
| Bildiri Dili | İngilizce |
| Kongre Adı | FENS Regional Meeting 2017 |
| Kongre Tarihi | 20-09-2017 / 23-09-2017 |
| Basıldığı Ülke | Macaristan |
| Basıldığı Şehir | Pécs |
