| Yazarlar (1) |
Dr. Öğr. Üyesi Betül YAZĞAN
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Impairment of insulin secretion induces to hyperglycemia and diabetes. The main stimulatory pathway for glucose-stimulated insulin secretion is ATP sensitive K+ channels and voltage-gated Ca2+ channel (VGCC). In the first step, glucose is transported into beta-cells through glucose transporter 2 and the glucose leads to a change in the ATP/ADP ratio resulting from ATP production in mitochondria. This induces membrane depolarization through direct blockade of ATP sensitive K+ channels. VGCC opens upon depolarization, causing the elevation of intracellular Ca2+ concentrations. Then, membrane potential changes drive pulsatile insulin secretion (Uchida et al. 2017). Apart from the VGCC, there is recently discovered Ca2+ channels namely transient receptor (TRP) channels. The Ca2+ permeable TRP melastatin 2 (TRPM2) is part of the TRP family, members of the melastatin and vanilloid subfamilies … |
| Anahtar Kelimeler |
| Bildiri Türü | Tebliğ/Bildiri |
| Bildiri Alt Türü | Özet Metin Olarak Yayınlanan Tebliğ (Uluslararası Kongre/Sempozyum) |
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum |
| Bildiri Dili | İngilizce |
| Kongre Adı | 7th World Congress ofOxidative Stress, Calcium Signaling and TRP Channels |
| Kongre Tarihi | 20-04-2018 / 23-04-2018 |
| Basıldığı Ülke | |
| Basıldığı Şehir |
