Glucocorticoid Receptor-β Is Downregulated by Vitamin D Treatment in Children with Low Vitamin D Levels but Not in Allergic Asthma
Yazarlar (6)
Prof. Dr. Şükrü Nail Güner Necmettin Erbakan Üniversitesi, Türkiye
Recep Sancak
Ondokuz Mayıs Üniversitesi, Türkiye
Ondokuz Mayıs Üniversitesi, Türkiye
Doç. Dr. Sedat GÜLTEN Kastamonu Üniversitesi, Türkiye
Ahmet Özen Marmara Üniversitesi, Türkiye
Mehtap Kılıç Ondokuz Mayis University, Medical School, Türkiye
Abdülkerim Bedir
Ondokuz Mayis University, Medical School, Türkiye
Ondokuz Mayis University, Medical School, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Pediatric Allergy Immunology and Pulmonology | ||
| Dergi ISSN | 2151-321X Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 09-2015 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-09-2015 |
| Cilt / Sayı / Sayfa | 28 / 3 / 144–151 | DOI | 10.1089/ped.2015.0506 |
| Makale Linki | http://dx.doi.org/10.1089/ped.2015.0506 | ||
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| Özet |
| BackgroundVitamin D (VitD) enhances the anti-inflammatory effects of glucocorticoids (GC) in vitro. It was hypothesized that VitD3 (colecalciferol) treatment could have an impact on the expression of glucocorticoid receptors (GRs) in a group of children with low VitD levels, with or without asthma.MethodsAsthmatic children and healthy controls, all with low serum VitD levels (25-hydroxyvitamin D [25(OH)D] level <30 ng/mL) were recruited. VitD3 treatment at a dose of 300,000 IU was given orally. Blood samples were obtained at admission and 1 month after the treatment to examine serum 25(OH)D levels and the relative gene expression (RGE) of GR-α and -β in peripheral blood mononuclear cells.ResultsTwenty-four children with asthma (Mage 11.1 ± 2.1 years) and 14 healthy controls (Mage 11.5 ± 1.7 years) were studied. The expression of GR-β was significantly higher in the control group at baseline … |
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| Scopus | 1 |
| Google Scholar | 1 |