Prognostic value of neutrophile-to-lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels for geriatric patients with COVID-19
Yazarlar (9)
Doç. Dr. Ugur Onal Kastamonu Training And Research Hospital, Türkiye
Muhammet Gulhan Kastamonu Training And Research Hospital, Türkiye
Nese Demirci Kastamonu Training And Research Hospital, Türkiye
Ahmet Ozden Kastamonu Training And Research Hospital, Türkiye
Nazlı Erol Kastamonu Training And Research Hospital, Türkiye
Öğr. Gör. Sema Isik Kastamonu Training And Research Hospital, Türkiye
Doç. Dr. Sedat GÜLTEN Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Fatma ATALAY Kastamonu Üniversitesi, Türkiye
Nilay Coplu Kastamonu Training And Research Hospital, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | BMC Geriatrics | ||
| Dergi ISSN | 1471-2318 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2022 |
| Kabul Tarihi | 14-04-2022 | Yayınlanma Tarihi | 25-04-2022 |
| Cilt / Sayı / Sayfa | 22 / 1 / 1–6 | DOI | 10.1186/s12877-022-03059-7 |
| Makale Linki | http://dx.doi.org/10.1186/s12877-022-03059-7 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Aim In this study it was aimed to evaluate the prognostic factors for the geriatric patients with confirmed COVID-19 in a tertiary-care hospital at Kastamonu region of Turkey. Method Patients (>= 65-year-old) who had PCR positivity for COVID-19 between March 2020 and April 2020 in our center were recorded retrospectively. A p value less than 0.05 was considered significant. Ethical committee approval was given from the Bolu University with decision number 2020/176. Results There were a total of 100 patients (44% female). In-hospital mortality was recorded as 7%. In univariate analysis for 1 month mortality, diabetes mellitus (p= 0.038), leucocyte count (p= 0.005), neutrophile count (p= 0.02), neutrophile-to-lymphocyte ratio (NLR)(p< 0.001), thrombocyte-to-lymphocyte ratio (TLR)(p= 0.001), C-reactive protein (CRP)(p= 0.002), lactate dehydrogenase (LDH)(p= 0.001), sequential organ failure assessment (SOFA) score (p= 0.001) and qSOFA score (p= 0.002) were found as independent risk factors. On admission, one point increase of NLR (p= 0.014, odds ratio (OR)= 1.371, 95% CI= 1.067-1.761) and one point increase of LDH (p= 0.047, OR= 1.011, 95% CI= 1.001-1.023) were associated with mortality on day 30 according to logistic regression analysis. The cut-off values were found as> 7.8 for NLR (83.33% sensitivity, 97.7% specificity) and> 300 U/L for LDH (100% sensitivity, 79.31% specificity) regarding the prediction of 30-day mortality. Conclusion In order to improve clinical management and identify the geriatric patients with COVID-19 who have high risk for mortality, NLR and LDH levels on admission might be useful prognostic tools. |
| Anahtar Kelimeler |
| Covid-19 | Geriatric patients | Neutrophile-to-lymphocyte ratio, lactate dehydrogenase | Prognostic factors |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 11 |
| Scopus | 11 |
| Google Scholar | 11 |