The anticancer effects of desferrioxamine on human breast adenocarcinoma and hepatocellular carcinoma cells
Yazarlar (6)
Osman Saliş
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Abdülkerim Bedir
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Veli Kılınç
Trabzon Public Health Laboratory, Türkiye
Trabzon Public Health Laboratory, Türkiye
Hasan Alaçam
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Sedat GÜLTEN Kastamonu Üniversitesi, Türkiye
Ali Okuyucu
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Cancer Biomarkers | ||
| Dergi ISSN | 1574-0153 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2014 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 10-10-2014 |
| Cilt / Sayı / Sayfa | 14 / 6 / 419–426 | DOI | 10.3233/CBM-140422 |
| Makale Linki | http://dx.doi.org/10.3233/cbm-140422 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| N-myc downstream-regulated gene 1 (NDRG1) is defined as metastasis suppressor and can be downregulated in many types of cancers, and reported to be an indication of tumor progression in hepatocellular carcinomas. Several in-vivo and in-vitro studies have demonstrated that iron chelators such as Desferrioxamine (DFO) and 1–10 Phenanthroline (PHEN) are effective antitumor agents. It is suggested that these chelators deliver their antitumor activity by acting on the NDRG1 gene expression. It remains unclear why NDRG1 gene expression affects the tumors differently, or becomes affected differently. We consider that this different effect might be caused by variants. Based on this information, we developed specific primers and probes for NDRG1 mRNA variants using bioinformatics analysis, and investigated how DFO and PHEN affected the dynamics of NDRG1 variant on the cell lines of Human Breast … |
| Anahtar Kelimeler |
| Desferrioxamine | Human breast adenocarcinoma and hepatocellular carcinoma | N-myc downstream-regulated gene 1 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 25 |
| Scopus | 27 |
| Google Scholar | 38 |