Cytotoxic Effect of Fluvastatin on MCF-7 Cells Possibly Through a Reduction of the mRNA Expression Levels of SGK1 and CAV1
Yazarlar (6)
Osman Saliş
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Abdülkerim Bedir
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Doç. Dr. Sedat GÜLTEN Kastamonu Üniversitesi, Türkiye
Ali Okuyucu
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Canan Külcü
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
Hasan Alaçam
Ondokuz Mayis Üniversitesi, Türkiye
Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Cancer Biotherapy and Radiopharmaceuticals | ||
| Dergi ISSN | 1084-9785 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 11-2014 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-11-2014 |
| Cilt / Sayı / Sayfa | 29 / 9 / 368–375 | DOI | 10.1089/cbr.2013.1593 |
| Makale Linki | http://dx.doi.org/10.1089/cbr.2013.1593 | ||
| UAK Araştırma Alanları |
Tıbbi Biyokimya
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| Özet |
| Fluvastatin (FLU) prevents the conversion of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) to mevalonic acid by inhibiting HMG-CoA reductase and decreases cholesterol level. Although the effects of FLU treatment on several cancer types through many mechanisms have been identified, its relationship with unfolded protein response and apoptosis has not been clearly understood. In this recent study, we aimed to investigate the cytotoxic effect of Fluvastatin on MCF-7 cells and define the transcriptional regulation of specific genes during the occurrence of this cytotoxic effect. We administered 0.62, 2.5, 5, and 40 μM FLU on MCF-7 cells singly and in combination with 2-deoxyglucose (2-DG), and we monitored cell viability and proliferation for 48 hours using real-time cell analyzer system (xCELLigence). At the same time, we measured the mRNA expression levels of glucose-regulated protein 78 (GRP78 … |
| Anahtar Kelimeler |
| CAV1 | Cytotoxic effect | Fluvastatin | MCF-7 | SGK1 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 7 |
| Scopus | 9 |
| Google Scholar | 15 |