| Yazarlar |
Sedanur Sancak
|
Doç. Dr. İdris YAZGAN
Kastamonu Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Aslı UĞURLU BAYARSLAN
Türkiye |
|
Adnan Ayna
Türkiye |
|
Senanur Evecen
|
|
Zehra Taşdelen
|
|
Abdurrahman Gümüş
İzmir Yüksek Teknoloji Enstitüsü, Türkiye |
|
Hamide Ayçin Sönmez
|
|
Mehmet Ali Demir
|
|
Sosin Demir
|
|
Fatma Bakar
|
|
Hafize Dilek Tepe
Türkiye |
|
Kaja Kasemets
|
|
Maarja Otsus
|
Prof. Dr. Talip ÇETER
Kastamonu Üniversitesi, Türkiye |
| Özet |
| Surface functionalized nanostructures have outstanding potential in biological applications owing to their target-specific design. In this study, we utilized laboratory synthesized carbohydrate-derivatives (i.e., galactose, mannose, lactose, and cellobiose derivatives) for aqueous one-pot synthesis of gold (Au) and silver (Ag) nanostructure glycoconjugates (NSs), and iron metal-organic framework glycoconjugates (FeMOFs). This work aims to test whether differences in the surface chemistry of the inorganic nanostructures play roles in revealing their toxicities towards bacterial cells and cancerous cell lines. As of the first step, biological activity of AuNSs, AgNSs, and FeMOFs were tested against a variety of gram (−) and gram (+) bacterial strains, where AgNSs possessed moderate to high antibacterial activities against all the tested bacterial strains, while AuNSs and FeMOFs showed their bacterial toxicity mostly depending on the strain. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) determination studies were performed for the nanostructure glycoconjugates, for which μg/mL MBC values were obtained such as (Cellobiose p-aminobenzoic acid_AgNS) CBpAB_AgNS gave 50 μg/mL MBC value for P.aeruginosa and S.kentucy. The activity of selected sugar ligands and corresponding glycoconjugates were further tested on MDA-MB-231 breast cancer and A549 lung cancer cell lines, where selective anticancer activity was observed depending on the surface chemistry as well. Besides, D-penicillamine was introduced to galectin specific sugar ligand coated AuNS glycoconjugates, which showed very strong anticancer activities even at low doses. Overall, the importance of this work is that the surface chemistry of the inorganic nanostructures can be critical to reveal their toxicity towards bacterial cells and cancerous cell lines. |
| Anahtar Kelimeler |
| And anticancer | Antibacterial | Carbohydrate derivatives | Nanostructure glycoconjugates |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Drug Delivery Science and Technology |
| Dergi ISSN | 1773-2247 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | Türkçe |
| Basım Tarihi | 12-2023 |
| Cilt No | 79 |
| Sayı | 1 |
| Sayfalar | 104054 / 0 |
| Doi Numarası | 10.1016/j.jddst.2022.104054 |
| Makale Linki | http://dx.doi.org/10.1016/j.jddst.2022.104054 |
| Atıf Sayıları | |
| SCOPUS | 3 |
