Surface chemistry dependent toxicity of inorganic nanostructure glycoconjugates on bacterial cells and cancer cell lines
Yazarlar (15)
Sedanur Sancak Kastamonu Üniversitesi, Türkiye
Prof. Dr. İdris YAZGAN Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Aslı Uğurlu Bayarslan Kastamonu Üniversitesi, Türkiye
Doç. Dr. Adnan Ayna Bingöl Üniversitesi, Türkiye
Senanur Evecen Kastamonu Üniversitesi, Türkiye
Zehra Taşdelen Kastamonu Üniversitesi, Türkiye
Doç. Dr. Abdurrahman Gümüş İzmir Yüksek Teknoloji Enstitüsü, Türkiye
Hamide Ayçin Sönmez Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Mehmet Ali Demir Kastamonu Üniversitesi, Türkiye
Sosin Demir Kastamonu Üniversitesi, Türkiye
Fatma Bakar
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Doç. Dr. Hafize Dilek Tepe Manisa Celâl Bayar Üniversitesi, Türkiye
Kaja Kasemets National Institute Of Chemical Physics And Biophysics, Estonya
Maarja Otsus National Institute Of Chemical Physics And Biophysics, Estonya
Prof. Dr. Talip ÇETER Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Drug Delivery Science and Technology (Q1) | ||
| Dergi ISSN | 1773-2247 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2023 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-01-2023 |
| Cilt / Sayı / Sayfa | 79 / 1 / 104054–0 | DOI | 10.1016/j.jddst.2022.104054 |
| Makale Linki | http://dx.doi.org/10.1016/j.jddst.2022.104054 | ||
| Özet |
| Surface functionalized nanostructures have outstanding potential in biological applications owing to their target-specific design. In this study, we utilized laboratory synthesized carbohydrate-derivatives (i.e., galactose, mannose, lactose, and cellobiose derivatives) for aqueous one-pot synthesis of gold (Au) and silver (Ag) nanostructure glycoconjugates (NSs), and iron metal-organic framework glycoconjugates (FeMOFs). This work aims to test whether differences in the surface chemistry of the inorganic nanostructures play roles in revealing their toxicities towards bacterial cells and cancerous cell lines. As of the first step, biological activity of AuNSs, AgNSs, and FeMOFs were tested against a variety of gram (−) and gram (+) bacterial strains, where AgNSs possessed moderate to high antibacterial activities against all the tested bacterial strains, while AuNSs and FeMOFs showed their bacterial toxicity mostly depending on the strain. Minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) determination studies were performed for the nanostructure glycoconjugates, for which μg/mL MBC values were obtained such as (Cellobiose p-aminobenzoic acid_AgNS) CBpAB_AgNS gave 50 μg/mL MBC value for P.aeruginosa and S.kentucy. The activity of selected sugar ligands and corresponding glycoconjugates were further tested on MDA-MB-231 breast cancer and A549 lung cancer cell lines, where selective anticancer activity was observed depending on the surface chemistry as well. Besides, D-penicillamine was introduced to galectin specific sugar ligand coated AuNS glycoconjugates, which showed very strong anticancer activities even at low doses. Overall, the importance of this work is that the surface chemistry of the inorganic nanostructures can be critical to reveal their toxicity towards bacterial cells and cancerous cell lines. |
| Anahtar Kelimeler |
| And anticancer | Antibacterial | Carbohydrate derivatives | Nanostructure glycoconjugates |
Science Direct
Surface chemistry dependent toxicity of inorganic nanostructure glycoconjugates on bacterial cells and cancer cell lines
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 10 |