| Yazarlar |
Giovanni M. Saladino
|
|
Nuzhet I. Kilic
|
|
Bertha Brodin
|
|
Bejan Hamawandi
|
Doç. Dr. İdris YAZGAN
Kastamonu Üniversitesi, Türkiye |
|
Hans M. Hertz
|
|
Muhammet S. Toprak
|
| Özet |
| Nanoparticle (NP)‐based contrast agents enabling different imaging modalities are sought for non‐invasive bio‐diagnostics. A hybrid material, combining optical and X‐ray fluorescence is presented as a bioimaging contrast agent. Core NPs based on metallic rhodium (Rh) have been demonstrated to be potential X‐ray Fluorescence Computed Tomography (XFCT) contrast agents. Microwave‐assisted hydrothermal method is used for NP synthesis, yielding large‐scale NPs within a significantly short reaction time. Rh NP synthesis is performed by using a custom designed sugar ligand (LODAN), constituting a strong reducing agent in aqueous solution, which yields NPs with primary amines as surface functional groups. The amino groups on Rh NPs are used to directly conjugate excitation‐independent nitrogen‐doped carbon quantum dots (CQDs), which are synthesized through citrate pyrolysis in ammonia solution. CQDs provided the Rh NPs with optical fluorescence properties and improved their biocompatibility, as demonstrated in vitro by Real‐Time Cell Analysis (RTCA) on a macrophage cell line (RAW 264.7). The multimodal characteristics of the hybrid NPs are confirmed with confocal microscopy, and X‐ray Fluorescence (XRF) phantom ex-periments. |
| Anahtar Kelimeler |
| Bio‐imaging | Carbon quantum dots | Contrast agents | Dual‐mode imaging | Hybrid nanostructure | Nanomedicine | X‐ray fluorescence |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Nanomaterials |
| Dergi ISSN | 2079-4991 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 08-2021 |
| Cilt No | 11 |
| Sayı | 9 |
| Sayfalar | 2165 / |
| Makale Linki | https://www.mdpi.com/2079-4991/11/9/2165 |
