Dose-dependent functions of fibroblast growth factor 9 regulate the fate of murine XY primordial germ cells
Yazarlar (4)
Dr. Öğr. Üyesi Ferhat ULU Kastamonu Üniversitesi, Türkiye
Sung-Min Kim
John A. Burns School Of Medicine, Amerika Birleşik Devletleri
John A. Burns School Of Medicine, Amerika Birleşik Devletleri
Toshifumi Yokoyama
John A. Burns School Of Medicine, Amerika Birleşik Devletleri
John A. Burns School Of Medicine, Amerika Birleşik Devletleri
Yukiko Yamazaki
John A. Burns School Of Medicine, Amerika Birleşik Devletleri
John A. Burns School Of Medicine, Amerika Birleşik Devletleri
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Biology of Reproduction | ||
| Dergi ISSN | 0006-3363 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 23-12-2016 |
| Cilt / Sayı / Sayfa | 96 / 1 / 122–133 | DOI | 10.1095/biolreprod.116.143941 |
| Makale Linki | https://academic.oup.com/biolreprod/article/96/1/122/2734431?login=true | ||
| UAK Araştırma Alanları |
Biyoenformatik
|
||
| Özet |
| Male differentiation of primordial germ cells (PGCs) is initiated by the inhibition of entry into meiosis and exposure to male-inducing factor(s), which are regulated by somatic elements of the developing gonad. Fibroblast growth factor 9 (FGF9) produced by pre-Sertoli cells is essential for male gonadal differentiation and also contributes to survival and male differentiation of XY PGCs. However, it is not clear how FGF9 regulates PGC fate. Using a PGC culture system, we identified dose-dependent, fate-determining functions of FGF9 in XY PGCs. Treatment with low levels of FGF9 (0.2 ng/ml) increased expression of male-specific Dnmt3L and Nanos2 in XY PGCs. Conversely, treatment with high levels of FGF9 (25 ng/ml) suppressed male-specific gene expression and stimulated proliferation of XY PGCs. Western blotting showed that low FGF9 treatment enhanced p38 MAPK (mitogen-activated protein kinase … |
| Anahtar Kelimeler |
| Cell proliferation | ERK1/2 signaling pathway | FGF9 | Male differentiation | P38 signaling pathway | XY primordial germ cells |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 11 |
| Scopus | 12 |
| Google Scholar | 13 |